Parametric Sequential Method for MRI-Based Wall Shear Stress Quantification.

Wall shear stress (WSS) has been suggested as a potential biomarker in various cardiovascular diseases and it can be estimated from phase-contrast Magnetic Resonance Imaging (PC-MRI) velocity measurements. We present a parametric sequential method for MRI-based WSS quantification consisting of a geometry identification and a subsequent approximation of the velocity field. This work focuses on its validation, investigating well controlled high-resolution in vitro measurements of turbulent stationary flows and physiological pulsatile flows in phantoms. Initial tests for in vivo 2D PC-MRI data of the ascending aorta of three volunteers demonstrate basic applicability of the method to in vivo.

MR-based wall shear stress measurements in fully developed turbulent flow using the Clauser plot method.

In arterial blood flow wall shear stress (WSS) quantifies the frictional force that flowing blood exerts on a vessel wall. WSS can be directly estimated from phase-contrast (PC) MR velocity measurements and has been suggested as a biomarker in cardio-vascular diseases. We present and investigate the application of the Clauser plot method for estimating WSS in fully developed turbulent stationary flow using PC velocity measurements. The Clauser plot method estimates WSS from the logarithmic region of boundary layer in fully developed turbulent stationary flow. The Clauser plot method was evaluated using 2D PC-MR phantom measurements at 3 T for different in-plane resolutions at various Reynolds numbers. WSS values derived from the Clauser plot were compared to results from Laser Doppler Velocimetry (LDV) measurements and theoretical results calculated using the friction factor formula for smooth pipe flow. For all Reynolds numbers, WSS values derived from the Clauser plot were in good agreement with results from LDV measurements and values using the friction factor formula (relative deviations ∼5%). Furthermore, Clauser plot derived results were almost independent of spatial resolution, in contrast to WSS results obtained with our in-house software tool for MR-based WSS quantification showing relative deviations of more than 100%. In fully developed turbulent flow, the Clauser plot method provides highly consistent WSS independent of the underlying spatial resolution. Therefore, it renders a valuable approach for MR-based WSS estimates in controllable flow settings. Although its direct in vivo applicability is severely limited because of the different flow character, it may serve as helpful approach for validation of MR-based WSS quantification algorithms prior to their clinical application.