1.
Biosci Biotechnol Biochem
; 80(7): 1436-9, 2016 Jul.
Article
in English
| MEDLINE
| ID: mdl-26966894
ABSTRACT
High glucose reduced the egg-laying rate of the nematode Caenorhabditis elegans and was dependent on serotonergic signaling. Antidiabetic drugs of the biguanide and thiazolidine classes ameliorated the detrimental effect of glucose on egg-laying rate, suggesting the possibility that this quick and easy assay system may be applicable to whole-animal screening for novel antidiabetic drugs, at least, of these classes.