ABSTRACT
Hair chromium concentration (HCC) of normal and diabetic pregnant women was determined by atomic-absorption spectroscopy. For nondiabetic pregnant women the value from 68 hair samples was 472 +/- 61 ng/g (mean +/- 95% CI); for gestational diabetics it was 734 +/- 155 ng/g from 42 hair samples. The difference was highly significant (P less than 0.005). Intermediate hair chromium concentrations were observed in 20 pregnant women with pregestational, overt diabetes mellitus (mean: 575 +/- 182 ng/g). Fifty-two women had a second hair sample taken later during pregnancy that showed a significant decrease in HCC (P less than 0.05). However, this decrease was confirmed only for the diabetic pregnant group. Age and parity did not influence the HCC. The data suggest that impaired utilization of chromium may be a possible etiology for gestational diabetes mellitus.
Subject(s)
Chromium/analysis , Diabetes, Gestational/metabolism , Hair/chemistry , Pregnancy in Diabetics/metabolism , Pregnancy/metabolism , Adult , Age Factors , Diabetes, Gestational/etiology , Female , Humans , ParityABSTRACT
A retrospective analysis was carried out to assess hormonal and sonographic characteristics of 52 conceptual (P-cycles) and 53 nonconceptual (F-cycles) gonadotropin treatment cycles in the same women. In the P-cycles, an exponential E2 pattern was observed up to the day of hCG (human chorionic gonadotropin) administration (day 0). In the F-cycle group, a similar pattern was observed till day (-1), and then levels plateaued. Forty-two (80.9%) of the pregnancies were achieved when the active phase was 6 +/- 1 days; seven pregnancies (14.8%) occurred when the active phase was more than 7 days. Only one of these pregnancies was a singleton viable pregnancy (P less than .05). It is, therefore, postulated that 6 +/- 1 days rising E2 and exponential E2 rise pattern up to the day of hCG are the two main monitoring variables leading to the highest percentage of viable singleton or twin pregnancies in hMG-stimulated cycles.
