[The influence of ursodeoxycholic acid on some biochemical, immunologic and histopathologic parameters in patients with primary biliary cirrhosis]. / Wplyw kwasu ursodezoksycholowego na niektóre parametry biochemiczne, immunologiczne oraz obraz histopatologiczny u chorych z pierwotna zólciowa marskoscia watroby.

UNLABELLED: Primary biliary cirrhosis (PBC) is a chronic, inflammatory disease, which affects the small and medium size bile ducts and is characterized by chronic cholestasis. Ursodeoxycholic acid (UDCA), that had earlier been used in treatment of cholesterol cholelithiasis, was introduced to pharmacotherapy of PBC 10 years ago. Our study was carried out in 30 patients, who were suffering from PBC and were treated at Department of Gastroenterology, Collegium Medicum, Jagiellonian University in Cracow. Beside the routine biochemical and enzymatic tests all patients had the level of immunoglobulin checked and selected ones acute phase protein. The percutaneous liver biopsy was carried out in each case; the morphological changes were classified according to Ludwig scale. All above tests were carried out before implementing UDCA as well as after one year from the beginning of the treatment. The group of patients is still closely monitored. CONCLUSIONS: 1. By using the UDCA in treatment of PBC biochemical parameters of cholestasis improved, also in some cases the inflammatory reaction decreased; 2. UDCA used in monotherapy had no influence on the process of fibrosis.

[Studies on the effect of Krynica mineral water from the "Zuber" spring on alcohol-damaged gastric mucosa in rats]. / Badania nad wplywem krynickiej wody mineralnej ze zródla "Zuber" na uszkodzona alkoholem blone sluzowa zoladka szczurów.

The study was performed to investigate the protective effect of mineral water "Zuber", "Zuber" with "Jan" and an antacid on the alcohol induced gastric mucosal injury in rats. It was shown that Alugastrin, a hyperosmotic liquid antacid, protects rat gastric mucosa against alcohol. In opposite, a hyperosmotic and alkaline mineral water "Zuber" increases a vulnerability of the gastric mucosa and worsen the damaging effect of alcohol on it. Izoosmotic mixture of mineral waters "Zuber" and "Jan", similarly to a physiologic saline, do not protect rat gastric mucosa. The study show that mineral waters "Zuber" and "Zuber" with "Jan" have a short-lasting neutralizing effect on the gastric HCl and in opposite to antacids have not protective properties on gastric mucosa.