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1.
Preprint in English | medRxiv | ID: ppmedrxiv-22269394

ABSTRACT

BackgroundAlthough high vaccine effectiveness of messenger RNA (mRNA) coronavirus disease 2019 (COVID-19) vaccines was reported in studies in several countries, data is limited from Asian countries, especially against the Delta (B.1.617.2) variant. MethodsWe conducted a multicenter test-negative case-control study in patients aged [≥]16 visiting hospitals or clinics with signs or symptoms consistent with COVID-19 from July 1 to September 30, 2021, when the Delta variant was dominant ([≥]90% of severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infections) nationwide in Japan. Vaccine effectiveness of BNT162b2 or mRNA-1273 against symptomatic SARS-CoV-2 infections was evaluated. Waning immunity among patients aged 16 to 64 was also assessed. ResultsWe enrolled 1936 patients, including 396 test-positive cases and 1540 test-negative controls for SARS-CoV-2. The median age was 49 years, 53.4% were male, and 34.0% had underlying medical conditions. Full vaccination (receiving two doses [≥]14 days before symptom onset) was received by 6.6% of cases and 38.8% of controls. Vaccine effectiveness of full vaccination against symptomatic SARS-CoV-2 infections was 88.7% (95% confidence interval [CI], 78.8-93.9) among patients aged 16 to 64 and 90.3% (95% CI, 73.6-96.4) among patients aged [≥]65. Among patients aged 16 to 64, vaccine effectiveness within one to three months after full vaccination was 91.8% (95% CI, 80.3-96.6), and was 86.4% (95% CI, 56.9-95.7) within four to six months. ConclusionsmRNA COVID-19 vaccines had high effectiveness against symptomatic SARS-CoV-2 infections in Japan during July 1 to September 30, 2021, when the Delta variant was dominant nationwide.

2.
Article in Japanese | WPRIM (Western Pacific) | ID: wpr-886212

ABSTRACT

A 76-year-old man presented with right leg numbness and general fatigue. The patient had no respiratory symptoms and negative PCR of COVID-19, but the lungs on CT scan revealed highly suspected COVID-19. The CT scan also showed occlusion from the right external iliac artery through below-knee arteries. Our surgical staff had personal protective equipment with powered air-purifying respirators and performed emergent surgical thrombectomy with the Fogarty balloon catheter. A few days after the operation, we found that the patient's antibody for COVID-19 was positive. The patient received anticoagulation and the postoperative course was uneventful. It is desirable to have more novel and precise knowledge of thrombosis in patients with COVID-19.

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