Subject(s)
Coronary Artery Bypass , Platelet Aggregation Inhibitors/pharmacology , Selective Serotonin Reuptake Inhibitors/pharmacology , Ticlopidine/analogs & derivatives , Antidepressive Agents, Second-Generation/pharmacology , Antidepressive Agents, Second-Generation/therapeutic use , Clopidogrel , Coronary Artery Disease/diagnosis , Coronary Artery Disease/drug therapy , Coronary Artery Disease/surgery , Depression/diagnosis , Depression/drug therapy , Drug Interactions , Humans , Prognosis , Selective Serotonin Reuptake Inhibitors/therapeutic use , Ticlopidine/pharmacologyABSTRACT
BACKGROUND: Aspartame (L-phenylalanine N-L-alpha-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours occurred. The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene. MATERIALS AND METHODS: After one week per os administration of various doses of aspartame to CBA/CA female mice, p53, c-myc, Ha-ras gene expression alterations were determined in individual organs. RESULTS: The results showed an increase in gene expressions concerning all the investigated genes especially in organs with a high proliferation rate: lymphoreticular organs, bone-marrow and kidney. CONCLUSION: Aspartame has a biological effect even at the recommended daily maximum dose.
Subject(s)
Aspartame/adverse effects , Genes, ras , Proto-Oncogene Proteins c-myc/biosynthesis , Sweetening Agents/adverse effects , Tumor Suppressor Protein p53/biosynthesis , Animals , Female , Gene Expression Regulation , Mice , Mice, Inbred Strains , Organ SpecificityABSTRACT
The importance of bacterial, viral and fungal diseases has significantly increased during the past decades. The reasons are numerous, but the most important ones are as follows: appearance of new variance of microbes, appearance and spread of antibiotic resistant bacterial strains, and increasing number of patients with various degree of immunodeficiency. For such reasons we consider extremely important to overview and upgrade our current knowledge and practice regarding to these diseases. This manuscript will discuss the hottest practical questions of dermato-infectology.
