ABSTRACT
Today, the majority of physicians no longer consider the well-informed patient to be something of a headache--rather, they welcome him as a partner in the management of his disease. The reason for this is that the more he knows about his illness, the more reliably will he comply with the physician's proposed treatment, the more readily he will be- come aware of side effects, and will thus actively contribute to his recovery. With the aid of easy-to-complete questionnaires, the state of knowledge of POAD patients about their disease was determined. The information thus gained may be considered the basis for an individual physician/patient talk.
Subject(s)
Arterial Occlusive Diseases/prevention & control , Patient Education as Topic , Peripheral Vascular Diseases/prevention & control , Blood Glucose/analysis , Body Mass Index , Cholesterol/blood , Counseling , Exercise , Humans , Obesity/complications , Physician-Patient Relations , Risk Factors , Smoking/adverse effects , Smoking Cessation , Surveys and QuestionnairesABSTRACT
Cerebral macrophages are supposed to exploit a pivotal role in scavenger functions of the central nervous system. We have examined the in vivo uptake of serum albumin and IgG conjugated with colloidal gold by subarachnoidal macrophages. These serum-borne proteins are endocytosed by receptor-mediated endocytosis by varying kinetics. Albumin-gold conjugates were found to be associated to a significant amount with coated pits and coated vesicles 1 min after superfusion of the cerebral surface. Within 25 min the major fraction of albumin-gold was transferred to the lysosomal compartment. IgG-conjugates revealed a less pronounced uptake. The uptake of albumin-gold could be competed by saturating of the 'receptor sites' with free albumin. It is suggested that the described receptor-mediated uptake of serum-borne proteins by subarachnoidal macrophages serves a cleansing function following blood-brain barrier disruption during acute or subacute inflammatory reactions.
