ABSTRACT
Hypokinesia effects on cardiac contractivity and vegetative regulation were studied in rats with high and low spontaneous motor activity. It was shown that hypokinesia promotes depression of the stroke volume and decrease of sympathetic nervous activity in rats with low motor activity. At the same time, in rats with high motor activity these parameters were not significantly affected by hypokinesia. The conclusion is made about a relationship between resistance to hypokinesia and spontaneous motor activity.
Subject(s)
Heart Rate/physiology , Motor Activity/physiology , Myocardial Contraction/physiology , Stroke Volume/physiology , Animals , Male , Rats , Restraint, PhysicalABSTRACT
Extracts of mammalian arterial walls revealed a kinin-like biological activity resistant against proteolytic inactivation with trypsin but not chymotrypsin. Bradykinin was chromatographically determined as kinin existing in extracts from the rat aorta. Kallidin was found as well as bradykinin in human vessels. Metabolism of vasoactive kinins in the vascular wall seems to take part in control of circulation and blood pressure.