History of physical and/or sexual abuse and current suicidality in college women.

OBJECTIVE: The purpose of this study was to examine the relationship between a history of physical and/or sexual abuse and current suicidality in college-age women. It was hypothesized that abuse history would significantly predict level of suicidality. A secondary hypothesis was that abuse status would predict attitudes about life and death. METHOD: Female college students (n = 707) were screened for histories of childhood (before age 15) and adulthood (after age 15) contact sexual abuse and physical abuse sequelae. Ninety-five women reported a history of childhood sexual abuse, 116 adult sexual abuse, 104 child physical abuse, and 55 adult physical abuse. Participants completed measures of attitudes about life and death and current suicidal ideation. RESULTS: Child physical abuse and child sexual abuse accounted for variance in current suicidal ideation. Adult sexual abuse explained variance in positive attitudes about life. Adult physical abuse, adult sexual abuse, and child sexual abuse accounted for variance in negative attitudes about life. Finally, child sexual abuse and adult sexual abuse accounted for variance in fear of death. CONCLUSIONS: Detailed assessment of female college students' abuse histories should facilitate understanding of their level of suicide risk. Patterns of attitudes about life and death may also be informative.

Docosahexaenoic acid reverses cyclosporin A-induced changes in membrane structure and function.

The use of a fish oil vehicle for cyclosporin A (CsA) can decrease the toxic effects of CsA but the mechanism is unclear. Here we examine the mechanism by which docosahexaenoic acid (DHA), a fish oil-derived polyunsaturated fatty acid, can alter the toxic effects of CsA on mouse organ function, endothelial macromolecular permeability, and membrane bilayer function. Mice given CsA and fish oil showed increased liver toxicity, kidney toxicity, incorporation of DHA, and evidence of oxidized fatty acids compared to control animals. We hypothesized that the toxic effects of CsA were primarily a result of membrane perturbation, which could be decreased if DHA were not oxidized. The presence of CsA (10 mol%) alone increased dipalmitoylphosphatidylcholine membrane permeability by seven fold over control (no CsA, no DHA). However, if non-oxidized DHA (15 mol%) and CsA were added to the membrane, the permeability returned to control levels. Interestingly, if the DHA was oxidized, the antagonistic effect of DHA on CsA was completely lost. While CsA alone increased endothelial permeability to albumin, the combination of non-oxidized DHA and CsA had no effect on endothelial macromolecular permeability. However the combination of oxidized DHA and CsA was no different than the effects of CsA only. CsA increased the fluorescence anisotropy of DPH in the liquid crystalline state of DPPC, while DHA decreased fluorescence anisotropy. However the combination of CsA and DHA was no different than DHA alone. We conclude that non-oxidized DHA can reverse the membrane perturbing effects of CsA, and the increases in endothelial macromolecular permeability, which may explain how fish oil is capable of decreasing the toxicity of CsA.

The effects of daily stressors on physical health in women with and without a childhood history of sexual abuse.

OBJECTIVE: The primary purpose of the present study was to examine the relationship between daily stressors and physical symptoms in college-age women with a childhood history of sexual abuse and women without a history of childhood sexual abuse. It was hypothesized that women with a history of childhood sexual abuse would be particularly susceptible to the effects of daily stressors on physical symptoms, and would show more covariation between daily stressors and physical symptoms, compared to women without a history of childhood sexual abuse. METHOD: Female college students (n = 491) were screened for histories of childhood (before age 15) and adulthood (after age 15) contact sexual abuse. Of these participants, 18 women with only a history of childhood sexual abuse were assigned to the SA group, and 27 women with no history of childhood or adulthood sexual abuse were assigned to the NA group. These women filled out self-report measures of daily hassles and physical symptoms for 28 consecutive days. RESULTS: During the 5 days preceding a highly stressful day, women in the SA group reported significantly more physical symptoms than during the 5 days preceding a day of low stress. For the NA group, there were no significant differences in reported physical symptoms between high- and low-stress days. CONCLUSIONS: The pattern of results for physical symptoms suggests that women with a history of childhood sexual abuse may be particularly susceptible to the effects of heightened daily stress, and may display this susceptibility in the report of physical symptoms. Possible explanations for these findings are discussed.

Exploration of the relationship between physical and/or sexual abuse, attitudes about life and death, and suicidal ideation in young women.

Experiencing sexual and/or physical abuse at any point in one's life can be quite traumatic. In addition to the immediate effects of the abuse, numerous long-term consequences have been identified, including an increased risk of developing psychological disorders and attempting suicide. We sought to determine if a relationship exists between abuse experiences, attitudes about life and death, and suicidal ideation by surveying 644 college women between the ages of 18 and 24. Participants completed packets containing standardized abuse questionnaires, the Multi-Attitude Suicide Tendency Scale, and the Adult Suicidal Ideation Questionnaire. We concluded that abuse plays a role in how these young women think about life and death. Specifically, less repulsion by death and more repulsion by life were reported by women with more significant abuse histories. In addition, these same women endorsed higher levels of current suicidal ideation. It was also determined that women who had experienced more abuse tended to have been in therapy for longer periods of time. Implications of this study for mental health professionals working with suicidal young adults are discussed.