ABSTRACT
The effect of cadmium administration (Cd 0.4 mg/kg, ip, intraperitoneally, daily for 30 days) on its accumulation, contents of 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) in different brain regions in growing and adult rats was investigated. Cadmium was found to significantly increase the levels of 5-HT and 5-HIAA in all the brain regions of adult rats while the levels of 5-HT and 5-HIAA were significantly decreased in most of the brain regions of growing rats. The accumulation of cadmium in all the brain regions was significantly more marked in growing rats compared to adults after identical exposure. In conclusion, there was an age difference in both the accumulation of cadmium and 5-HT turnover in the brain regions. However, the regional neurochemical changes were not correlated with the magnitude of cadmium accumulation in both the groups.
Subject(s)
Aging/metabolism , Brain/growth & development , Cadmium/toxicity , Nervous System Diseases/chemically induced , Animals , Brain/metabolism , Cadmium/administration & dosage , Cadmium/metabolism , Cerebellum/metabolism , Cerebral Cortex/metabolism , Corpus Striatum/metabolism , Hippocampus/metabolism , Hydroxyindoleacetic Acid/metabolism , Hypothalamus/metabolism , Male , Medulla Oblongata/metabolism , Nervous System Diseases/metabolism , Pons/metabolism , Rats , Rats, Inbred Strains , Serotonin/metabolism , Tissue DistributionABSTRACT
A new patellar angle is described in lateral radiographs of the knee joint. One line is drawn along the articular surface of the patella and another from the end of the inferior articular cartilage to the patellar apex. The angle formed by these two lines averaged 33 degrees in 68 knees joints afflicted with Osgood-Schlatter disease and 47 degrees in 71 age-matched controls and 198 adult controls. The small angle in Osgood-Schlatter disease is proposed to be an important factor in the pathogenesis of the traction apophysitis.
