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1.
Oncologist ; 28(8): 657-663, 2023 08 03.
Article in English | MEDLINE | ID: mdl-37285045

ABSTRACT

In May 2019, the US Food and Drug Administration (FDA) released the Framework for FDA's Real-World Evidence (RWE) Program, a draft guidance to evaluate the potential use of real-world data in facilitating regulatory decisions. As a result, pharmaceutical companies and medical communities see patient registries, which are large, prospective, noninterventional cohort studies, as becoming increasingly important in providing evidence of treatment effectiveness and safety in clinical practice. Patient registries are designed to collect longitudinal clinical data on a broad population to address critical medical questions over time. With their large sample sizes and broad inclusion criteria, patient registries are often used to generate RWE in the general and underrepresented patient populations that are less likely to be studied in controlled clinical trials. Here, we describe the value of industry-sponsored patient registries in oncology/hematology settings to healthcare stakeholders, in drug development, and in fostering scientific collaboration.


Subject(s)
Drug Industry , Humans , Prospective Studies , Treatment Outcome , Registries
2.
J Clin Neurosci ; 19(3): 411-4, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22277560

ABSTRACT

We aimed to describe a single institution experience of neuroimaging failure to demonstrate malignant primary brain tumors. We retrospectively reviewed case histories for all newly diagnosed adult patients with malignant primary brain tumors treated at a single institution between 1 July 2006 and 30 June 2008. We specifically looked at patients in whom neuroimaging was normal or non-diagnostic at initial presentation. Among 193 patients with malignant primary brain tumors, there were 102 with World Health Organization (WHO) grade IV gliomas (glioblastoma multiforme, GBM), 54 with anaplastic gliomas, 18 with low grade gliomas, and 19 with primary central nervous system lymphomas (PCNSL). Initial imaging was normal in nine patients and abnormal but non-diagnostic in an additional eight patients with primary brain cancer. Normal or non-diagnostic neuroimaging was not uncommon among patients with GBM. Dramatic, rapid tumor growth is possible. Close interval clinical and radiographic follow-up can be important especially in the management of elderly patients presenting with seizures and non-diagnostic neuroimaging studies.


Subject(s)
Brain Neoplasms/diagnosis , Brain Neoplasms/pathology , Aged , Aged, 80 and over , Alcoholism/complications , Biopsy , Brain Neoplasms/diagnostic imaging , Carotid Stenosis/complications , Carotid Stenosis/diagnosis , Epilepsy, Complex Partial/complications , Epilepsy, Complex Partial/diagnosis , Epilepsy, Tonic-Clonic/diagnosis , Epilepsy, Tonic-Clonic/pathology , Female , Glioblastoma/diagnosis , Glioblastoma/pathology , Glioma/diagnosis , Glioma/diagnostic imaging , Glioma/pathology , Humans , Image Processing, Computer-Assisted , Immunohistochemistry , Lymphoma/diagnosis , Lymphoma/diagnostic imaging , Lymphoma/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Myotonic Dystrophy/diagnosis , Myotonic Dystrophy/pathology , Neuroimaging , Paresis/diagnosis , Paresis/pathology , Retrospective Studies , Seizures/complications , Seizures/diagnosis , Tomography, X-Ray Computed , Tumor Suppressor Protein p53/metabolism
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