ABSTRACT
Caecal bascule refers to a rare condition wherein the caecum folds upon the ascending colon causing intestinal obstruction. We describe a case report of caecal bascule following lung transplantation which required right hemicolectomy. It was initially thought to be due to post-operative paralytic ileus which is, not uncommonly, seen following lung transplantation. While most cases of paralytic ileus respond to conservative measures, it is important to maintain a close watch-keeping in mind a high degree of suspicion for possible surgically correctable causes, which can be a lifesaving intervention. The clinical dilemma in subjecting a heavily immunosuppressed patient, soon after lung transplantation (where painless abdominal distention is not uncommon), to a major abdominal surgery in the background of minimal clinical signs of acute abdomen is discussed. The thought process behind the surgical strategy, including the pros and cons of various surgical options and the management of nutrition and immunosuppression in this patient, is elaborated.
ABSTRACT
Venoarterial (VA) extracorporeal life support (ECLS) or extracorporeal membrane oxygenation (ECMO) as it is commonly known is used in many clinical situations to support both the pumping action of the heart and the gas exchange function of the lungs. This review hopes to refresh, in the mind of the reader, aspects of basic physiological principles that have relevance in VA ECLS therapy. The dynamics of the interaction of the machine with the patient and vice versa plays an important role in clinical outcome. An understanding of the variation from normal physiology imposed both by the machine and the disease process will help make enlightened decisions in the use of this challenging therapy. The key physiological changes during initiation, maintenance, and weaning are discussed as well as certain specific clinical scenarios.
ABSTRACT
Vasoplegia observed post cardiopulmonary bypass (CPB) is associated with substantial morbidity, multiple organ failure and mortality. Circulating counts of hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPC) are potential markers of neo-vascularization and vascular repair. However, the significance of changes in the circulating levels of these progenitors in perioperative CPB, and their association with post-CPB vasoplegia, are currently unexplored. We enumerated HSC and EPC counts, via flow cytometry, at different time-points during CPB in 19 individuals who underwent elective cardiac surgery. These 19 individuals were categorized into two groups based on severity of post-operative vasoplegia, a clinically insignificant vasoplegic Group 1 (G1) and a clinically significant vasoplegic Group 2 (G2). Differential changes in progenitor cell counts during different stages of surgery were compared across these two groups. Machine-learning classifiers (logistic regression and gradient boosting) were employed to determine if differential changes in progenitor counts could aid the classification of individuals into these groups. Enumerating progenitor cells revealed an early and significant increase in the circulating counts of CD34+ and CD34+CD133+ hematopoietic stem cells (HSC) in G1 individuals, while these counts were attenuated in G2 individuals. Additionally, EPCs (CD34+VEGFR2+) were lower in G2 individuals compared to G1. Gradient boosting outperformed logistic regression in assessing the vasoplegia grouping based on the fold change in circulating CD 34+ levels. Our findings indicate that a lack of early response of CD34+ cells and CD34+CD133+ HSCs might serve as an early marker for development of clinically significant vasoplegia after CPB.
