Single-Metallic Thermoresponsive Coordination Network as a Dual-Parametric Luminescent Thermometer.

The single-metallic coordination networks (CNs), simultaneously exhibiting temperature-dependent lifetime (TDLT) and emission band shift (TDEBS), are desirable for application in luminescent thermometers with high accuracy and reliability in a large temperature range. Nonetheless, up to date, there are no reports on such kinds of materials due to the lack of in-depth understanding of the origin of TDLT and TDEBS at a molecule level, being critical for exploiting a universal approach to design a dual-parametric CN phosphorescent thermometer (CN-PT). Herein, we have constructed a thermoresponsive CN [Cu2(L1)Br2]∞ (IAM21-1, L1 = N1,N6-di(pyridin-3-yl)adipamide) via a flexible-ligand-implanted strategy. The TDLT and TDEBS properties of IAM21-1 enable it to be applied as a single-metallic dual-parametric CN-PT in 50-500 K, which is the widest temperature range reported so far. The combination of structure analysis and DFT calculations demonstrates that the redshift of the emission band upon the decreasing temperature originates from the reversible skeleton-shrinkage-triggered narrower band gap. This work has unveiled the origin of TDLT and TDEBS properties and proposed an efficient strategy for designing dual-parametric CN-PTs.

Chronic prostatitis/chronic pelvic pain syndrome and prostate cancer: study of immune cells and cytokines.

Prostate cancer and prostatitis are both significant health concerns. A large number of studies have established that the occurrence of the two is closely related. However, the most common prostatitis, type III chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS), is reported to not correlate with the occurrence of prostate cancer. Although the etiology of CP/CPPS is unknown, it may be related to the autoimmune mechanism favored by most studies. Manipulating the immune system and targeting tumor microenvironment are promising new methods for the treatment of prostate cancer. Therefore, this review focuses on the immune cells and cytokines of CP/CPPS and prostate cancer from the perspective of biological immunology and immune microenvironment. We discuss T-regulatory (Treg) and T helper 17 (Th17) cells dysfunction, the abnormal regulation of T helper 1(Th1) and T helper 2 (Th2) cells, macrophages, and their related cytokines as key activators in CP/CPPS. In addition, we discuss the roles of Treg and Th17 cells, Th1 and Th2 cells, and related cytokines in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines provide a research strategy for the etiology of CP/CPPS and offer potentially promising targets for the treatment of prostate cancer.

Intentional anion incorporation to rationally modulate the size, shape and optical properties of lanthanide oxide nanocrystals.

Incorporating impure foreign atoms or ions has been extensively utilized in materials science for generating hybrid materials with desirable properties and functions. Despite most materials consisting of cations and anions, conventional routes only focus on incorporating cations. In this work, we proposed an intentional impure anion incorporation strategy as a facile and straightforward route to adjust the properties of yielded nanocrystals. Via incorporating diverse anions, the size, morphology, uniformity and optical properties of lanthanide oxide nanocrystals could be rationally tuned. Furthermore, the obtained nanocrystals could further serve as a bioprobe for imaging deep tissue.

Mg(II) Coordination Polymers Based on Flexible Isomeric Tetracarboxylate Ligands: Syntheses, Structures, Structural Transformation and Luminescent Properties.

By using a new flexible tetracarboxylic acid, bis(3,5-dicarboxyphenyl) adipoamide, H4L¹, and its isomer, bis(2,5-dicarboxyphenyl)adipoamide, H4L², three Mg(II) coordination polymers, {[Mg2(L¹)(H2O)2]·2EtOH·3H2O}n, 1, [Mg2(L¹)(H2O)8]n, 2, and {[Mg2(L²)(H2O)6]·H2O}n, 3, have been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction. Complexes 1 and 2 are the solvent ratio-dependent hydrothermally stable products. The tetracarboxylate ligand of complex 1 connects eight Mg(II) ions through nine oxygen atoms, resulting in a three-dimensional (3D) 5-connected uninodal net with a rare non-interpenetrating (44.66)-pcu-5-Pmna topology, whereas those of 2 and 3 link four Mg(II) ions through four oxygen atoms and six Mg(II) ions through six oxygen atoms, forming a 1D linear chain and a 3,6-connected 2-nodal 3D net having {4.6²}2{4².610.8³}-rtl topology, respectively. Complex 1 shows a series of structural transformations on heating to 200 °C and almost reversible structural transformation when the activated products were immersed in a mixture of ethanol and water or on hydrothermal. Likewise, complex 2 exhibits a reversible structural transformation on heating/hydrothermal, while 3 exhibits irreversible structural transformations. All three complexes exhibit blue light emissions, with that of complex 3 being much more intense.