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1.
J Infect Dis ; 176(6): 1625-8, 1997 Dec.
Article in English | MEDLINE | ID: mdl-9395379

ABSTRACT

An outbreak of gastrointestinal illness with clinical and epidemiologic features of enterotoxigenic Escherichia coli (ETEC) occurred among patrons of a restaurant during April 1991. Illnesses among several groups of patrons were characterized by diarrhea (100%) and cramps (79%-88%) lasting a median of 3-5 days. Median incubation periods ranged from 50 to 56 h. A nonmotile strain of E. coli (E. coli O39), which was negative for heat-labile (LT) and heat-stable (STa, STb) ETEC toxins, was isolated only from ill patrons. This organism produced enteroaggregative E. coli heat-stable enterotoxin 1 and contained the enteropathogenic E. coli gene locus for enterocyte effacement; it did not display mannose-resistant adherence, but produced attaching and effacing lesions in the absence of mannose on cultured HEp-2 cells. E. coli that are not part of highly characterized but narrowly defined groups may be important causes of foodborne illness.


Subject(s)
Diarrhea/microbiology , Disease Outbreaks , Escherichia coli Infections/epidemiology , Escherichia coli Infections/microbiology , Escherichia coli Proteins , Escherichia coli/isolation & purification , Food Microbiology , Bacterial Adhesion , Bacterial Toxins/analysis , Bacterial Toxins/metabolism , Bacteriological Techniques , Cell Line , Enterotoxins/analysis , Enterotoxins/metabolism , Escherichia coli/classification , Escherichia coli/immunology , Escherichia coli/pathogenicity , Humans , Mannose/metabolism , O Antigens/analysis , Seroepidemiologic Studies
2.
Chest ; 85(3): 307-10, 1984 Mar.
Article in English | MEDLINE | ID: mdl-6321112

ABSTRACT

Serum angiotensin-converting enzyme (SACE) levels were measured in 44 subjects six weeks after acute pulmonary histoplasmosis. All patients were infected in a common-source outbreak of histoplasmosis which occurred on one day. All patients had both strictly defined clinical and serologic evidence of infection. The SACE activity was elevated at six weeks compared to normal controls, and seven of the 44 had levels more than 2 SD above the normal mean. SACE levels were also measured at three and 24 weeks after acute infection in a smaller number of the same subjects. Serial observations demonstrated that all subjects (including those with normal and elevated SACE at six weeks) had a rise and fall in SACE activity following symptomatic acute pulmonary histoplasmosis. Our findings suggest that elevated SACE does not reliably separate sarcoidosis from histoplasmosis, although elevations in histoplasmosis are much less common and may occur only briefly following acute pulmonary histoplasmosis. More important, it seems that SACE activity rises acutely in all patients with symptomatic acute histoplasmosis and then falls gradually toward baseline over several months, coinciding temporally with the granulomatous response.


Subject(s)
Histoplasmosis/enzymology , Lung Diseases, Fungal/enzymology , Peptidyl-Dipeptidase A/blood , Acute Disease , Adult , Diagnosis, Differential , Granuloma/pathology , Histoplasmosis/diagnosis , Humans , Lung Diseases, Fungal/diagnosis , Sarcoidosis/diagnosis
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