Current evidence on laparoscopic vs. open resection for gastric stromal tumours.

Although the use of laparoscopic surgery is increasing, controversy still surrounds its application for malignant conditions. Gastrointestinal stromal tumours (GISTs) are less demanding in terms of lymphadenectomy, meaning that laparoscopic resection might have a more defined benefit when compared with open resection. To the best of our knowledge, no randomized study exists that compares the laparoscopic and open resection of GISTs. The current study aimed to examine the relevant literature by means of a systematic review. A systematic literature search was performed individually by two authors, in which three independent databases were searched using specific search-terms. Titles, abstracts and full texts were screened, as well as references to relevant articles, in order to comprise a comprehensive list of studies. Data were extracted using a detailed pre-agreed spreadsheet. Studies were evaluated according to the modified MINORS criteria. A total of 10 studies were included in the present review, yielding a total of 14 entries. The majority of studies reported significantly improved perioperative outcomes for the laparoscopic approach, including improved duration of operation, blood loss and length of hospital stay. Only four studies reported long-term outcomes and findings that were controversial, with some studies detecting no statistically significant differences, one reporting improved and one reporting worse disease-free and overall survival for the laparoscopic group. Three studies were deemed to be good quality, two of which had not reported significantly different long-term outcomes, while the third had reported significantly improved outcomes in the open resection group. While there is a clear benefit for performing laparoscopic surgery in patients with GIST with regards to perioperative outcomes, when it comes to long-term oncological outcomes, uncertainty over its application remains. The lack of randomized trials, as well as the poor reporting of retrospective studies, limits the amount of evidence that is currently available. Laparoscopic surgery for GIST is certainly safe, feasible and likely cost-effective; however, further studies are required to inform on whether this technique is superior to open resection.

Reevaluating the prognostic value of RAS mutation status in patients with resected liver metastases from colorectal cancer: A systematic review and meta-analysis.

BACKGROUND: Although the value of Rat Sarcoma Oncogene (RAS) mutation status in predicting long-term outcomes in patients with colorectal liver metastases (CRLM) is widely accepted, the magnitude of its impact has recently been challenged by three large cohort studies. The aim of this meta-analysis is to reevaluate the impact of RAS mutations on overall survival (OS) and disease-free survival (DFS) in patients who underwent curative-intent resection of CRLM. METHODS: A comprehensive literature search was performed for studies reporting outcomes of patients undergoing curative-intent surgery stratified by RAS mutation status. Exclusion criteria were defined a priori. Subgroup analysis was performed to evaluate the effect of publication date, sample size, and KRAS vs any RAS mutation on overall outcomes. RESULTS: Ten studies incorporating 3115 patients with known RAS status were identified. Pooled results revealed significantly worse OS (Hazard Ratio 1.5, 95% CI 1.31-1.71) and DFS (Hazard Ratio 1.36, 95% CI 1.22-1.52) in RAS-mutated patients. Subgroup analyses revealed that studies including more than 300 patients or published after 2015 reported lower HR than their counterparts. CONCLUSION: The results of this meta-analysis suggest that the prognostic value of RAS mutation status in patients with CRLM has been previously overestimated.

Laparoscopic repair of an excessive Morgagni hernia in an adult presenting as upside-down stomach.

INTRODUCTION: Morgagni hernia is defined as the intrathoracic protrusion of abdominal viscera through a defect in the anterior diaphragm. It represents an uncommon type of diaphragmatic congenital hernia. CASE PRESENTATION: A 68-year-old female patient was admitted in our department due to progressive epigastric discomfort for the past four months. A preoperative diagnosis of a paraesophageal hernia was set through computer tomography, with gastric portions and parts of small bowel protruding inside the thoracic cavity. Intraoperatively, an excessive diaphragmatic defect was detected in the anterior side of the diaphragm. Reduction of the hernia's contents inside the abdominal cavity was achieved through laparoscopy, with the additional fixation of an intraperitoneal non-absorbable mesh for reinforcement of the diaphragmatic wall. Patient was discharged uneventfully on the 4th postoperative day. DISCUSSION: Morgagni hernias refer to a rare type of diaphragmatic congenital hernias, usually identified during childhood, leaving only a small number of cases observed in the adult population. Its diagnosis can pose a challenge due to the non-specific and usually asymptomatic presentation. An early surgical management is advised due to an increased number of potentially lethal complications, such as gastric incarceration and obstruction. Treatment consist of open surgical techniques through a trans-thoracic or a trans-abdominal approach, although a paradigm shift in the 21st century considers minimal invasive laparoscopic surgery the treatment of choice. CONCLUSSION: A high index of clinical suspicion is required for diagnosis of Morgagni hernias, while prompt management is advised. Laparoscopy is considered the best approach in the hands of an experienced surgeon.

Evaluation and Testing of Junctional Tourniquets by Special Operation Forces Personnel: A Comparison of the Combat Ready Clamp and the Junctional Emergency Treatment Tool.

BACKGROUND: Previous research has shown that external hemorrhage from proximal leg amputations and junctional sites represents 19.2% of potentially survivable lethal hemorrhage. A recent effort to address this problem has resulted in the development of various junctional tourniquets. This study assessed and compared two Tactical Combat Casualty Care Committee-approved junctional tourniquets, the Combat Ready Clamp (CRoC) and the Junctional Emergency Treatment Tool (JETT), to contribute to their future development and to better inform on the decisions for device selection by military units. Aims of the study also were to provide concrete feedback and suggestions on how to effectively apply the devices. METHODS: Via a specific questionnaire, 75 international attendees of the International Special Training Centre Medical Branch Special Operations Forces Advanced Medical First Responder course evaluated the CRoC and the JETT on different parameters. Both devices were tested objectively through timed applications aimed at stopping unilateral lower-extremity distal pulse on 33 of these 75 students, verified by palpation by Medical Branch instructors. Subjective and objective data were examined for mutual correlation. RESULTS: Users ranked the JETT higher than the CRoC on all parameters, including effectiveness on the battlefield (ρ < .001), ease of use (ρ < .039), speed of application (ρ < .001), and not slipping in use (ρ < .001), although the difference on other parameters such as effectiveness in hemorrhage control was not statistically significant. Considering all parameters together, the JETT was evaluated as a better device than the CRoC (ρ < .001). The application time measurement suggested that the JETT was applied faster (by approximately 15 seconds on average; ρ < .001). The fastest CRoC and JETT applications were 37 and 29 seconds, respectively. The JETT was not easier to use or more effective than the CRoC; there was a 9% failure rate of the JETT occluding a unilateral common femoral artery. The JETT's efficacy in occluding a unilateral common femoral artery can be compromised if the device's pelvic binder is not sufficiently tightened prior to threading the T-handled pad. The CRoC's application time can be drastically reduced if the device is kept assembled and firm pressure is immediately asserted upon placement on the intended location through the vertical arm, then threading the device. Both devices were applied safely; no adverse effects were reported during or after application. CONCLUSION: Even though the JETT might be preferred by military medical providers, the CRoC still has merits. As both devices proved to occlude the arterial flow in no less than 54 seconds on average, they could be used to supplement direct pressure and wound packing, the latter two still being considered the immediate actions for inguinal bleeding control. Considering that the CRoC and the JETT can be applied in as little as 37 and 29 seconds, respectively, users should be effectively trained and entirely proficient on either device to justify their election as the primary countermeasure to hemorrhage not amenable to regular tourniquets.

Evolution of glucose intolerance and diabetes in transfused patients with thalassemia.

OBJECTIVE: To study the evolution of glucose disturbances (GD) in patients with thalassemia aged 11-30 years. DESIGN AND METHODS: A total of 263 patients, classified into three groups on the basis of age, and period of follow-up ranging from 2-10 years, were studied. Evolution of GD was assessed through serial oral glucose tolerance tests (OGTT), based on WHO criteria. RESULTS: At baseline (11-14 years of age) evaluation of OGTT disclosed a prevalence of 16.3% of impaired glucose tolerance (IGT), and zero for diabetic tolerance (DT). Prevalence of IGT increased progressively up to 39% in the following 4 years, but remained constant during the last 6 years of observation. In contrast, DT had a very low prevalence, beginning with 0.5% at 13-16 years, increasing to 2.4% by the age of 21-24 years. CONCLUSIONS: During puberty and early adolescence impaired glucose tolerance (IGT) was found in a considerable proportion of thalassemics. In contrast, DT was infrequent and progression to DM was slow. Only 12.4% of patients with IGT developed DT within a period of 10 years. Further studies are necessary to identify all of the factors contributing to abnormalities of glucose metabolism in thalassemic patients.