ABSTRACT
Recent research on the standard of care and related quality of life of the spinal cord-afflicted community in South Africa (SA) has revealed significant gaps in practice, and challenges regarding levels of care and access to services and supplies specifically related to the neurogenic bladder.
Subject(s)
Health Services Accessibility/organization & administration , Spinal Cord Injuries/complications , Urinary Bladder, Neurogenic/therapy , Clinical Protocols , Hospitalization , Humans , Practice Guidelines as Topic , South Africa , Urinary Bladder, Neurogenic/etiologyABSTRACT
To date over 150 X linked mental retardation (XLMR) conditions have been documented. We describe a five generation South African family with XLMR, comprising 16 affected males and 10 carrier females. The clinical features common to the 16 males included profound mental retardation (100%), mutism despite apparently normal hearing (100%), grand mal epilepsy (87.5%), and limited life expectancy (68.8%). Of the four affected males examined, all had mild craniofacial dysmorphology and three were noted to have bilateral ophthalmoplegia and truncal ataxia. Three of 10 obligate female carriers had mild mental retardation. Cerebellar and brain stem atrophy was shown by cranial imaging and postmortem examination. Linkage analysis shows the gene to be located between markers DXS424 (Xq24) and DXS548 (Xq27.3), with a maximum two point lod score of 3.10.
Subject(s)
Abnormalities, Multiple/genetics , Genetic Linkage , X Chromosome , Adult , Behavioral Symptoms , Cerebellum/abnormalities , Craniofacial Abnormalities/genetics , Epilepsy/genetics , Facies , Female , Genetic Markers , Heterozygote , Humans , Intellectual Disability/genetics , Male , Microsatellite Repeats , Models, Genetic , Ophthalmoplegia/genetics , Pedigree , South AfricaABSTRACT
Using Hasson's Wing Sound I to determine uterine segmental measurements in 160 women it was found that no constant relationship exists between total uterine axial length and cervical length; therefore uterine cavity size cannot be determined by standard sounding. The importance of fitting an intra-uterine contraceptive device to the endometrial cavity is discussed.
Subject(s)
Intrauterine Devices , Uterus/anatomy & histology , Anthropometry , Female , HumansSubject(s)
Analgesics/therapeutic use , Intrauterine Device Expulsion , Intrauterine Devices, Copper/adverse effects , Pain/drug therapy , Pyrroles/therapeutic use , Tolmetin/therapeutic use , Adolescent , Adult , Double-Blind Method , Female , Follow-Up Studies , Humans , Intrauterine Device Expulsion/adverse effects , Tolmetin/analogs & derivativesABSTRACT
In a series of 604 White women in whom intra-uterine contraceptive devices had been inserted, it was found that the Multiload Cu 250 performed significantly better than the Lippes loop. The occurrence of pregnancies in patients with the intra-uterine device in situ, as well as expulsion of the device, was three times higher with the Lippes loop than with the Multiload. The critical importance of correct insertion is stressed.
Subject(s)
Intrauterine Devices, Copper , Intrauterine Devices , Adolescent , Adult , Female , Follow-Up Studies , Humans , PregnancyABSTRACT
Amikacin, a new semisynthetic aminoglycoside antibiotic, was administered parenterally to 20 patients suffering from severe Gram-negative bacterial infections. The antibiotic was found to be highly effective in controlling infection. It was well tolerated and no signs of nephro- or otoxicity were observed. The few side-effects which were seen appeared to be dose-related. The recommended 12-hourly dosage regimen has also proved useful in medium- to long-term management of refractory pulmonary infections.
