ABSTRACT
BACKGROUND: Lung cancer is the second most common cancer and leading cause of cancer mortality worldwide. Recent advances in molecular testing and targeted therapy have improved survival among patients with metastatic non-small-cell lung cancer (NSCLC). We sought to quantify and describe molecular testing among metastatic non-squamous NSCLC cases in selected Southeast Asian countries and describe first-line therapy chosen. PATIENTS AND METHODS: A retrospective study was conducted based on incident lung cancer cases diagnosed between 2017 and 2019 in Lampang (Thailand), Penang (Malaysia), Singapore and Yogyakarta (Indonesia). Cases (n = 3413) were defined using the International Classification of Diseases for Oncology third edition. In Singapore, a clinical series obtained from the National Cancer Centre was used to identify patients, while corresponding population-based cancer registries were used elsewhere. Tumor and clinical information were abstracted by chart review according to a predefined study protocol. Molecular testing of epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) gene rearrangement, ROS1 gene rearrangement and BRAF V600 mutation was recorded. RESULTS: Among 2962 cases with a specified pathological diagnosis (86.8%), most patients had non-squamous NSCLC (75.8%). For cases with staging information (92.1%), the majority presented with metastatic disease (71.3%). Overall, molecular testing rates in the 1528 patients with stage IV non-squamous NSCLC were 67.0% for EGFR, 42.3% for ALK, 39.1% for ROS1, 7.8% for BRAF and 36.1% for PD-L1. Among these patients, first-line systemic treatment included chemotherapy (25.9%), targeted therapy (35.6%) and immunotherapy (5.9%), with 31% of patients having no record of antitumor treatment. Molecular testing and the proportion of patients receiving treatment were highly heterogenous between the regions. CONCLUSIONS: This first analysis of data from a clinically annotated registry for lung cancer from four settings in Southeast Asia has demonstrated the feasibility of integrating clinical data within population-based cancer registries. Our study results identify areas where further development could improve patient access to optimal treatment.
Subject(s)
Carcinoma, Non-Small-Cell Lung , Lung Neoplasms , Humans , Carcinoma, Non-Small-Cell Lung/drug therapy , Lung Neoplasms/drug therapy , B7-H1 Antigen , Anaplastic Lymphoma Kinase/genetics , Protein-Tyrosine Kinases/genetics , Protein-Tyrosine Kinases/therapeutic use , Proto-Oncogene Proteins B-raf/genetics , Retrospective Studies , Mutation , Proto-Oncogene Proteins/genetics , Proto-Oncogene Proteins/therapeutic use , Thailand , ErbB Receptors/geneticsABSTRACT
PURPOSE: To describe pupil block glaucoma in phakic and pseudophakic patients after vitrectomy with silicone oil injection. DESIGN: Interventional case series. METHODS: Cases were collected from January 1997 to July 2000 from three tertiary referral centers. RESULTS: Seven phakic patients (seven eyes) and one pseudophakic patient (one eye) presented 1 to 90 days after vitrectomy and silicone oil injection with intraocular pressures of 36 to 70 mm Hg. Five patients had an observed or potential weakness of the iris-lens diaphragm. Treatment with Nd:YAG-laser peripheral iridotomy or inferior iridectomy provided a temporary reduction in intraocular pressure for some patients, but all eventually required removal of silicone oil. CONCLUSION: Pupil block glaucoma after silicone oil injection is well recognized in aphakic patients, but ophthalmologists should be aware that it can occur in phakic and pseudophakic patients, particularly in complicated cases and patients with a weakness of the iris-lens diaphragm.
Subject(s)
Glaucoma, Angle-Closure/etiology , Lens, Crystalline , Pseudophakia/complications , Silicone Oils/adverse effects , Vitrectomy/adverse effects , Adult , Female , Glaucoma, Angle-Closure/surgery , Humans , Injections , Intraocular Pressure , Iris/surgery , Laser Therapy , Male , Middle Aged , Retinal Detachment/surgeryABSTRACT
15 cases each of Type II Reaction, LL and TT Leprosy and 50 endemic controls were studied for phenotypic markers T2, T4 and T8 by 2 step immunoperoxidase technique. There was statistically significant increase in T4 (helper) cells in Type II Reaction. There was also a decrease in T8 cells but this was not statistically significant.
Subject(s)
Leprosy, Lepromatous/immunology , Leprosy, Tuberculoid/immunology , T-Lymphocytes, Helper-Inducer/immunology , T-Lymphocytes, Regulatory/immunology , Adult , Antibodies, Monoclonal , Drug Therapy, Combination , Humans , Immunoenzyme Techniques , Leprosy, Lepromatous/drug therapy , Leprosy, Tuberculoid/drug therapy , Male , Middle Aged , Reference ValuesABSTRACT
The findings on the positivity of paper spot test and the mean DDS/Cr. ratios in relation to the percentage of treatment taken by 316 leprosy out-patients on 100, 50 or 25 mg/DDS daily are presented. Thirty-three percent of the subjects on 25 mg were found to give negative spot test as against 11-12% in the patient groups on 50 and 100 mgs dose schedules. The mean DDS/Cr. ratios in the spot test negative urine specimens were consistent for all dosage groups and ranged from 7.1-9.6 micrograms/mg. The ratios in the spot test-positive urine specimens, showed, in general, a direct proportion to the percentage of treatment taken particularly, in the 75-100% and 50-75% groups. The significance and implications of the findings are discussed.
