Diversity in phenol-metabolizing capability of 809 strains of micromycetes.

The property of 809 strains of micromycetes to grow in the presence of phenol (0.5 g/l) was investigated on solid media. Toxicity was determined on malt extract agar medium. Growth of the fungal strains on synthetic solid medium with phenol as the sole carbon source allowed evaluation of phenol consumption. Only 61 strains (8% of the whole) grew well under both conditions, which reflects the toxicity of 0.5 g/l of phenol upon micromycetes. Finally, Phanerochaete chrysosporium was chosen and cultivated in liquid synthetic medium at 24 degrees C and 37 degrees C with phenol (0.5 g/l). It consumed phenol fast and efficiently. Growth temperature was a key parameter. Catechol, cis-cis-muconic acid and beta-keto-adipate were characterized and quantified.

[N-aryl pyrrole derivatives with analgesic and anti-inflammatory activity 2. Pharmacologic modulation of the 1-arylpyrrole model]. / Dérivés N-aryl pyrroliques à activité analgésique et anti-inflammatoire. 2ème Partie--Pharmaco-modulation du modèle aryl-1 pyrrole.

In order to increase the pharmacological activities of the molecules described in the first part of the paper, an acetic or a 2-propionic group was introduced in to the fundamental structure, either on the aromatic ring, on the pyrrole nitrogen or on carbon 3 of the heterocycle. Moreover, a 4-chlorobenzoyl group was fixed on carbon 3 of the pyrrole via condensation of 4-chloroaniline with 4-chlorobenzoyl triketones. The structure of the adducts was demonstrated both by N.M.R. spectra and by using another unambiguous synthetic route. Finally, derivatives with the salicylic substructure on the nitrogen of the pyrrole are described. Their analgesic and anti-inflammatory properties are reported as well as some effects on the central nervous system.

[N-aryl pyrrol derivatives with analgesic and anti-inflammatory activity. 1. 1-Arylpyrroles substituted at positions 4 and 5]. / Dérivés N-aryl pyrroliques à activité analgésique et anti-inflammatoire. 1ère Partie. Aryl-1 pyrroles di substitués en 4 et 5.

The derivatives in question are prepared by reaction of substituted anilines with 1,4-ketones in an acidic medium. The diketones are themselves obtained either using Friedel and Crafts reaction with levulinic acid chloride, or by Stetter's method reacting Mannich bases with aryl aldehydes in the presence of sodium cyanide. The results of test of acute toxicity and of analgesic and anti-inflammatory activity are reported.