Genetic Associations Between Executive Functions and a General Factor of Psychopathology.

OBJECTIVE: Symptoms of psychopathology covary across diagnostic boundaries, and a family history of elevated symptoms for a single psychiatric disorder places an individual at heightened risk for a broad range of other psychiatric disorders. Both twin-based and genome-wide molecular methods indicate a strong genetic basis for the familial aggregation of psychiatric disease. This has led researchers to prioritize the search for highly heritable childhood risk factors for transdiagnostic psychopathology. Cognitive abilities that involve the selective control and regulation of attention, known as executive functions (EFs), are a promising set of risk factors. METHOD: In a population-based sample of child and adolescent twins (n = 1,913, mean age = 13.1 years), we examined genetic overlap between both EFs and general intelligence (g) and a transdiagnostic dimension of vulnerability to psychopathology, comprising symptoms of anxiety, depression, neuroticism, aggression, conduct disorder, oppositional defiant disorder, hyperactivity, and inattention. Psychopathology symptoms in children were rated by children and their parents. RESULTS: Latent factors representing general EF and g were highly heritable (h2 = 86%-92%), and genetic influences on both sets of cognitive abilities were robustly correlated with transdiagnostic genetic influences on psychopathology symptoms (genetic r values ranged from -0.20 to -0.38). CONCLUSION: General EF and g robustly index genetic risk for transdiagnostic symptoms of psychopathology in childhood. Delineating the developmental and neurobiological mechanisms underlying observed associations between cognitive abilities and psychopathology remains a priority for ongoing research.

Developmental transformations in the structure of executive functions.

Comparisons of results from studies of executive function (EF) in early childhood to those of EF in middle and late childhood suggest that individual differences in EFs may differentiate from a unitary factor in early childhood to an increasingly multidimensional structure in middle childhood and adolescence. We tested whether associations among EFs strengthened from middle childhood to adolescence using cross-sectional data from a population-based sample of 1019 children aged 7-15 years (M = 10.79 years). Participants completed a comprehensive EF battery consisting of 15 measures tapping working memory, updating, switching, and inhibition domains. Moderated factor analysis, local structural equation modeling, and network modeling were applied to assess age-related differences in the factor structure of EF. Results from all three approaches indicated that working memory and updating maintained uniformly high patterns of covariation across the age range, whereas inhibition became increasingly differentiated from the other three domains beginning around 10 years of age. However, consistent with past research, inhibition tasks were only weakly intercorrelated. Age-related differences in the organization of switching abilities were mixed.