Hand-foot syndrome induced changes of the palmar epidermal ridge configurations during and after treatment with capecitabine.

Palmar plantar erythrodysesthesia (hand-foot syndrome, HFS) is a common adverse event of treatment with cytostatic chemotherapeutics such as capecitabine. Histopathological findings are nonspecific and may even include generalized epidermal necrolysis. A total of 50 patients were examined before and after the intake of capecitabine to assess if HFS may result in relevant changes of the palmar epidermal ridge configurations with possible consequences for the patients who want to travel abroad. In total, 14 of the 50 patients developed HFS (28%) with HFS grades 1-3 observed. HFS grade 4 was not observed. HFS of grade 2 and 3 was associated with a temporary macroscopic loss of the epidermal ridges. No dactyloscopic changes that might have led to a false identification were seen in those cases. Patients with a risk of HFS development who want to travel abroad should carry a medical pass of the chemotherapeutic treatment to prevent them from difficulties in identification controls.

The Bielefeld Longitudinal Study of Adult Twins (BiLSAT).

The Bielefeld Longitudinal Study of Adult Twins (BiLSAT) is a German longitudinal study of monozygotic and dizygotic twins reared together, including more than 1,100 twin pairs aged between 14 and 80 who participated in the first wave. Data were collected at five waves of assessment between 1993 and 2009. Initially, the study focused on genetic and environmental influences on the structure and the development in adult temperament and personality. Today, the study includes a broad range of individual variables, such as personality disorders, major life goals, interests, attitudes, values, life and work satisfaction, and major life events. A special feature of this genetically informative study lies in the multiple-rater approach (i.e., self-reports and peer reports). Longitudinal multiple-rater analyses allow researchers to go beyond the basic nature-nurture decomposition of variance in self-reports examining genetic and environmental influences on stability and change in more accurately measured individual attributes. In the current article, we briefly describe the design and contents of BiLSAT as well as some recent major findings and future plans.

Sources of cumulative continuity in personality: a longitudinal multiple-rater twin study.

This study analyzed the etiology of rank-order stability and change in personality over a time period of 13 years in order to explain cumulative continuity with age. NEO five-factor inventory self- and peer report data from 696 monozygotic and 387 dizygotic twin pairs reared together were analyzed using a combination of multiple-rater twin, latent state-trait, and autoregressive simplex models. Correcting for measurement error, this model disentangled genetic and environmental effects on long- and short-term convergent valid stability, on occasional influences, and on self- and peer report-specific stability. Genetic factors represented the main sources that contributed to phenotypic long-term stability of personality in young and middle adulthood, whereas change was predominantly attributable to environmental factors. Phenotypic continuity increased as a function of cumulative environmental effects, which became manifest in stable trait variance and decreasing occasion-specific effects with age. This study's findings suggest a complex interplay between genetic and environmental factors resulting in the typical patterns of continuity in personality across young and middle adulthood.