ABSTRACT
We report on a 2023 outbreak of severe hand, foot, and mouth disease in southern Vietnam caused by an emerging lineage of enterovirus A71 subgenogroup B5. Affected children were significantly older than those reported during previous outbreaks. The virus should be closely monitored to assess its potential for global dispersal.
Subject(s)
Enterovirus Infections , Enterovirus , Hand, Foot and Mouth Disease , Child , Humans , Enterovirus/genetics , Vietnam/epidemiology , Hand, Foot and Mouth Disease/epidemiology , Enterovirus Infections/epidemiology , Lower Extremity , Antigens, ViralABSTRACT
Objective: To assess the influences of the knowledge of parents about hepatitis B virus (HBV) infection and the benefit of HBV vaccination on the practice of HBV vaccination among children. Methods: A prospective cross-sectional study recruited parents whose children, aged 12-24 months, received HBV vaccination at Commune Health Centers (CHCs) in Ho Chi Minh City from Feb. 2016 to Jul. 2017. Parents were interviewed using a questionnaire that included 11-item binary knowledge questions and checked their children's vaccination cards. Results: A total of 768 parents had a mean age of (30.8±5.1) years. The mean knowledge score of the 11- item questions was (7.0±2.4). The knowledge score was positively associated with full and timely HBV vaccination. In addition, children who received complete and timely HBV vaccination were significantly more likely to live in rural areas (Adjusted OR 4.02, 95% CI 2.79-5.79, P<0.001). Also, children whose parents received vaccination information from health care providers, and had knowledge about HBV risk, had a higher rate of full and timely HBV vaccination (Adjusted OR 1.60, 95% CI 1.13-2.29, and Adjusted OR 1.47, 95% CI 1.01-2.13, P all<0.05). Conclusions: Parents possessed a great deal of incorrect knowledge about HBV. More health education from health care providers should target parents living in specific locations and focus on the benefits of HBV vaccine.
ABSTRACT
A novel coumarin derivative (5) was synthesized and used as a colorimetric and fluorescent probe for selective detection of Cu2+ ions in the presence of other metal ions, with the detection limits of 5.7 and 4.0 ppb, respectively. Cu2+ ion reacts with probe 5 to form a 1:1 stoichiometry complex, resulting in a remarkable redshift of absorption maximum from 460 to 510 nm, as well as almost completely quenching fluorescence intensity of probe 5 at the wavelength of 536 nm. These changes can be distinctly observed by naked eyes. In addition, the working pH range of probe 5 is wide and suitable for physiological conditions, thus probe 5 may be used for detection of Cu2+ ions in living cells. The stable structures of probe 5 and its 1:1 complex with Cu2+ ion were optimized at the PBE0/6-31+G(d) level of theory. The presence and characteristics of bonds in compounds were studied through atoms in a molecule and natural bond orbital analysis. The formation of the complex led to a strong transfer of electron density from probe 5 as a ligand to Cu2+ ion, resulting in breaking the π-electron conjugated system, which is the cause of fluorescence quenching and color change of 5-Cu2+ complex.
ABSTRACT
Low-molecular-weight compounds with anticoagulant activity were isolated from the scorpion Heterometrus laoticus venom. The determination of the structure of the isolated compounds by nuclear magnetic resonance and mass spectrometry showed that one of the isolated compounds is adenosine, and the other two are dipeptides leucyl-tryptophan and isoleucyl-tryptophan. The anticoagulant properties of adenosine, which is an inhibitor of platelet aggregation, is well known, but its presence in scorpion venom is shown for the first time. The ability of leucyl-tryptophan and isoleucyl-tryptophan to slow down blood clotting and their presence in scorpion venom are also established for the first time.
Subject(s)
Anticoagulants/chemistry , Anticoagulants/pharmacology , Scorpion Venoms/chemistry , Scorpions , Animals , Mice , Molecular WeightABSTRACT
Background: Postperitoneal tumors are diseases that are difficult diagnosis, vague and unspecific clinical signs. Objective: To take out experience for clinical practice based on clinical, imaging diagnosis, pathological characteristics and management for postperitoneal tumors. Subjects and method: A retrospective study included 93 cases that diagnosed and treated for postperitoneal tumors at Cho Ray Hospital from January 2000 to November 2006. Clinical, subclinical characteristics and theirs related factors; diagnosis, operation and prognosis for postperitoneal tumors were analysed. Results: The patients\ufffd?average age was 49.98\xb116.37 years (ranged 1-85 years); the ratio of male to female was 0.86. The average time from having pain symptom to admitting hospital was 4.49\xb110.01 months (ranged from 3 days to 60 months). Clinical symptoms were fatigue (51.5%), fever (15%), jaundice (45%), anemia (23.5%), weight loss (58%), abdominal pain (75%), abdominal distention (39%), digestive disorders (31%), touching tumor (50.5%)\ufffd?The diagnosis at admitting were right (32%), wrong (60%) and unclear (8%); the preoperative diagnosis were 70%, 22% and 8%, respectively. Pathologically, 39 of 93 cases (42%) were benign tumors, and 58% were malignant tumors. 61.3% of cases removed completely tumors, 2.15% removed partially tumors. The postoperative outcomes were good (62.6%), unimproved (28.57%), and bad (3.29%). There were some complications, included perioperative bleeding (2 cases - 2.19%), postoperative complication (3 cases - 3.29%), cracked colonic junction (1 case), renal bleeding (1 case) and peritonitis (1 case). Conclusions: The surgical treatment was main method for postperitoneal tumors. The complete tumor removing based on tumor\u2019s nature, stage and related structures.
Subject(s)
Retroperitoneal Neoplasms , Therapeutics , Diagnosis , EpidemiologyABSTRACT
170 patients with perforated peptic ulcer (90% perforated duodenal ulcer and 10% perforated gastric ulcer) were included in the study from 8/1998 to 8/1999 at the Cho Ray hospital, Ho Chi Minh city. 165 patients (97.05%) were treated by simple surgical closure (including by one laparoscopic repair) with a postoperative mortality of 4.84%. 4 of them were treated by subtotal gastrectomy and one by vagotomy+ pyloroplasty without mortality. In summary, simple surgical closure is a satisfactory operation for most patients.
Subject(s)
Peptic Ulcer , Therapeutics , General SurgeryABSTRACT
The Aims of this study were to investigate to the role of Helicobacter pylori (H. pylori) eradication in cases of perforated peptic ulcer treated by simple surgical closure. In a large prospective study, these patients with H. pylori positive were evaluated before and after H. pylori eradication (>2 months and >1 year). Changes of gastric mocosal histopathology were assessed. Results: Improvement or resolution on the outcome of gastritis and atrophy (P<0.001) demonstrated the efficacy of eradication therapy but intestinal metaplasia did not change. Conclusions: After successful eradication of H. pylori, these lesions were restored significantly, but intestinal metaplasia is questionable
Subject(s)
Helicobacter pylori , Peptic UlcerABSTRACT
98 patients with perforated peptic ulcer were treated by simple surgical closure followed by H.pylori eradication. Effect of H.pylori eradication was demonstrated by improvement or resolution of histopathological lesions of chronic gastritis 97.95% compared with 60.2% in pre and postreatment lesions (p<0.0001), atrophy 20.83% vs 4.16% (p<0.0001) and intestinal metaplasia 18.75% vs 9.37% (p < 0.005). After successful eradication of H.pylori, these lesions were restored and improved significantly in patients received a new triple therapy for 7 days (OCA-7).
Subject(s)
Peptic Ulcer , Helicobacter pylori , General SurgeryABSTRACT
Of 115 patients with perforated peptic ulcer, 96,5% (111/115) were treated by simple surgical closure followed by Helicobacter pylori (H.pylori) eradication. 111 H.pylori positive patients received triple therapy including Omeprazole 20 mg b.d + Clarithromycine 500mg b.d + Amoxicillin 1,000 mg b.d for 7 days (OCA-7). Follow -up endoscopiy was performed over 2 month and over 1 year after hospital discharge for surveillance of ulcer healing and determination of H.pylori status. Of 107 patients who did underwent follow-up endoscopy, 95.3% (102/107) had H.pylori eradicated and initial ulcer healing rate was 92.5% (99/107). After over 1 year, H. pylori reinfection rate was 16.8% (16/95) and ulcer ralapse rate was 7.4% (7/95). The simple surgical closure followed by H.pylori eradication prevents ulcer recurrence in patients with H.pylori associated perforated peptic ulcers.