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Bioorg Med Chem Lett
; 12(3): 505-7, 2002 Feb 11.
Article
in English
| MEDLINE
| ID: mdl-11814829
ABSTRACT
Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the standard binary Vinca alkaloids.