ABSTRACT
A case of Gorham disease with several years of follow-up is reported. At birth he had a mass in the thigh which was had pathology demonstrating a lymphangioma. By age 3 years, he had lymphedema of the ipsilateral foot and discrepant leg lengths. Radiography revealed heterogenous dystrophy of the bones and osteolysis of the hallux. At age 6, a spontaneous fracture of the right tibia was treated with surgery. Histopathology of a bone sample demonstrated bone remodelling, fibrous tissue, and large vascular lacunas within bone tissue, bordered by cells expressing the lymphaticmarker D2-40. At 8 years old, lymphedema of the right inferior leg had increased, leg lengths still differed, but other clinical signs were absent.
Subject(s)
Femoral Fractures/pathology , Hallux/pathology , Lymphangioma/pathology , Lymphedema/pathology , Osteolysis, Essential/pathology , Age of Onset , Child , Child, Preschool , Femoral Fractures/diagnostic imaging , Femoral Fractures/surgery , Follow-Up Studies , Hallux/diagnostic imaging , Humans , Infant , Infant, Newborn , Lymphangioma/diagnostic imaging , Male , Osteolysis, Essential/diagnostic imaging , Osteolysis, Essential/surgery , RadiographyABSTRACT
Tumor-to-tumor metastasis is a very rare event. We report three cases of tumor metastasizing in another tumor: a clear cell renal cell carcinoma in a vesicular thyroid adenoma, a lung carcinoma in a meningioma and a neuroendocrine lung carcinoma in a clear cell renal cell carcinoma. According to the literature, clear cell renal cell carcinoma is the most common tumor recipient of metastasis while lung carcinoma is the most common donor tumor. Several physiopathological mechanisms can explain this phenomenon, but many of them are still unknown.
