ABSTRACT
Nine patients with severe Rh iso-immunization were treated by plasma exchange combined with immunosuppression. Apart from 3 abortions, previous pregnancy losses consisted of 7 intra-uterine and 5 neonatal deaths. Only 2 patients had had no previous pregnancy loss. Differences in the optical density of the amniotic fluid of 8 patients fell into the upper Liley zone. There was one intra-uterine death due to abruptio placentae but no neonatal deaths. When the outcome of the pregnancy immediately preceding the treatment pregnancy was compared to the treatment pregnancy, the fetal loss was reduced from 6 to 1. No adverse fetal effects were encountered.
Subject(s)
Immunosuppression Therapy , Plasmapheresis , Rh Isoimmunization/therapy , Adult , Combined Modality Therapy , Female , Humans , Pregnancy , Severity of Illness IndexABSTRACT
An infant milk formula specially designed to meet the specific needs of the small premature infant was compared with a modified infant milk formula in common use. Healthy infants of very low birth weight were fed with either the specially designed infant milk formula or the standard modified infant milk formula. No statistically significant differences between the two groups of infants were found, although the weight gain, skinfold thickness, serum total protein, albumin and calcium values were marginally better at 28 days in the group fed with the specially designed formula.
Subject(s)
Food, Formulated , Infant Nutritional Physiological Phenomena , Infant, Low Birth Weight , Milk , Animals , Clinical Trials as Topic , Female , Humans , Infant, Newborn , Male , Random AllocationABSTRACT
Plasma aminograms of infants receiving total parenteral nutrition as part of the treatment for necrotizing enterocolitis were studied. Their ages varied from 2 to 60 days and their mean birth mass was 1 621 g (range 760-2 550 g). The intravenous administration of amino acids produced changes in plasma amino acid levels corresponding to the concentration of individual amino acid levels in the solution employed: higher levels of amino acids in the infusate produced increased plasma levels, whereas low plasma levels were obtained for amino acids not present or present in small amounts according to the solution used. The infants did not appear to suffer in any way, but the long-term effects still have to be evaluated. Pending further knowledge in this regard it is suggested that plasma amino acid levels should be maintained as near to normal values as possible. This could probably be achieved by the use of amino acid solutions specially formulated according to the amino acid profile of breast milk or the plasma amino acid profile of normal infants.
Subject(s)
Amino Acids/administration & dosage , Enterocolitis, Pseudomembranous/therapy , Infant, Newborn, Diseases/blood , Parenteral Nutrition, Total , Parenteral Nutrition , Amino Acids/blood , Enterocolitis, Pseudomembranous/blood , Humans , Infant , Infant, Newborn , Injections, IntravenousSubject(s)
Osteochondrodysplasias/congenital , Thoracic Diseases/congenital , Humans , Infant, Newborn , Male , SyndromeABSTRACT
The clinical, cytogenetic and dermatoglyphic findings in a patient with a ring chromosome 21 are presented. This anomaly acts as a deletion of chromosomal material and results in specific congenital defects. A comparison is made with 24 cases of deletions involving chromosome 21 described in the literature. Six of these have been studied by means of recently developed chromosome banding techniques. Cases presumably arise through somatic non-disjunction or chromosome breakage. When the chromosomes of both parents are normal the recurrence risk is negligible.
