ABSTRACT
Scombroid poisoning, systemic mastocytosis, and hereditary alpha tryptasemia all present with episodes that resemble allergic reactions. Knowledge regarding systemic mastocytosis and hereditary alpha tryptasemia is quickly evolving. Epidemiology, pathophysiology, and strategies to identify and diagnose are discussed. Evidence-based management in the emergency setting and beyond is also explored and summarized. Key differences are described between these events and allergic reactions.
Subject(s)
Anaphylaxis , Angioedema , Mast Cell Activation Disorders , Mastocytosis, Systemic , Mastocytosis , Humans , Mastocytosis/diagnosis , Mastocytosis/genetics , Mast Cells/physiology , Mastocytosis, Systemic/diagnosis , Mastocytosis, Systemic/genetics , Angioedema/diagnosis , Angioedema/epidemiology , Angioedema/etiology , Tryptases/genetics , Anaphylaxis/diagnosisABSTRACT
Scombroid poisoning, systemic mastocytosis, and hereditary alpha tryptasemia all present with episodes that resemble allergic reactions. Knowledge regarding systemic mastocytosis and hereditary alpha tryptasemia is quickly evolving. Epidemiology, pathophysiology, and strategies to identify and diagnose are discussed. Evidence-based management in the emergency setting and beyond is also explored and summarized. Key differences are described between these events and allergic reactions.
