ABSTRACT
Cytogenetic studies of osteochondromas are scarce but have previously shown recurring clonal aberrations involving chromosome 8. We have studied a series of eight tumors and have found recurring aberrations not only involving chromosome 8, but also chromosome 1 in five of the seven abnormal tumors. Surprisingly, three of the chromosome 1 aberrations involved pericentric inversions. Four tumors showed aberrations involving the region 1p13 approximately p22 by mechanisms including inversion, insertion, and translocation. These findings indicate that aberrations of chromosome 1p, in a region spanning 1p13 approximately p22, may be nonrandomly involved in the cytogenetic progression of osteochondroma.
Subject(s)
Chromosome Breakage/genetics , Chromosomes, Human, Pair 1/genetics , Osteochondroma/genetics , Adolescent , Child , Child, Preschool , Chromosome Banding , Chromosomes, Human, Pair 8/genetics , Female , Humans , Karyotyping , Male , Translocation, Genetic/geneticsABSTRACT
Benign meningiomas are characterized by a normal karyotype or loss of all or part of chromosome 22. Histologically higher grade tumors are typically characterized by a pattern of increasing chromosome loss and instability. This characteristic pattern of unbalanced chromosome aberrations is punctuated in the literature by several intriguing reports of a reciprocal t(1;19)(q21;q13.3) as the sole cytogenetic aberration. We report a third case showing the t(1;19)(q21;q13.3) with additional unstable secondary aberrations of a dic(18;22)(p11;p11) and telomeric fusions.
