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1.
J Am Chem Soc ; 137(40): 12788-91, 2015 Oct 14.
Article in English | MEDLINE | ID: mdl-26436636

ABSTRACT

The nickel-catalyzed coupling of enones or enals with alkynes in the presence of silane and titanium alkoxide reductants provides direct access to skipped diene products. The process involves a net four-electron reductive coupling and proceeds with deoxygenation of the starting enone or enal. A new class of well-defined nickel(0) precatalysts bearing an unhindered N-heterocyclic carbene ligand, which was developed in optimization of the process, is essential for the efficiency of the transformation. The strategy allows the high reactivity of α,ß-unsaturated carbonyl substrates to be utilized in couplings with simultaneous extrusion of the oxygen atom, thus enabling a traceless strategy for alkene installation.

2.
Org Lett ; 13(13): 3289-91, 2011 Jul 01.
Article in English | MEDLINE | ID: mdl-21657241

ABSTRACT

The reductive coupling of enones or enals with alkynes, followed by olefin oxidative cleavage and Paal-Knorr cyclization, provides a versatile entry to a variety of pyrrole frameworks. A number of limitations of alternate entries to the requisite 1,4-dicarbonyl intermediate are avoided. Classes of pyrroles that are accessible by this approach include 2,3-, 2,4-, 1,2,3-, 1,2,4-, 2,3,5-, and 1,2,3,5-substituted monocyclic pyrroles as well as a number of fused-ring polycyclic derivatives.


Subject(s)
Alkynes/chemistry , Ketones/chemistry , Pyrroles/chemistry , Heterocyclic Compounds/chemistry , Molecular Structure , Oxidation-Reduction
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