ABSTRACT
A genomic expression library of Streptococcus pneumoniae was screened with a convalescent-phase serum for immunoreactive proteins. Six known and 17 unknown pneumococcal proteins were detected. Five of the known proteins were surface-located virulence factors, and eight of the unknown proteins were putative membrane proteins.
Subject(s)
Antibodies, Bacterial/blood , Antigens, Bacterial/isolation & purification , Bacterial Proteins/isolation & purification , Membrane Proteins/isolation & purification , Pneumococcal Infections/immunology , Bacterial Proteins/immunology , Convalescence , Membrane Proteins/immunology , VirulenceSubject(s)
Insurance, Health/economics , Parental Leave/economics , Pregnancy Complications/economics , Pregnancy , Female , Humans , Insurance, Health/statistics & numerical data , Maternal Welfare , Parental Leave/statistics & numerical data , Pregnancy Complications/epidemiology , Sweden/epidemiologyABSTRACT
Following a presumptive treatment with 35 mg chloroquine base/kg, 484 Namibian children between 5 months and 5 years of age received 50 mg of proguanil daily for 4 months. They were compared with 268 children living in a very adjacent area who received vitamin tablets after the initial chloroquine medication. Fewer fever episodes were recorded among the children who received proguanil and they were also requiring less presumptive treatments with chloroquine during the period of study, but there were only minor differences in parasite rate between the two groups at the end of the study period. Despite the reduction of morbidity, the required efforts were too large to justify another period of drug prophylaxis.
