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2.
Int J Endocrinol ; 2016: 6169721, 2016.
Article in English | MEDLINE | ID: mdl-27087809

ABSTRACT

The purpose of this study is to identify the prevalence of osteoporosis in male patients with chronic obstructive pulmonary disease (COPD) by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) and to compare the diagnostic abilities of the above methods. Thirty-seven male patients with established COPD were examined with DXA and standard QCT in lumbar spine, including L1, L2, and L3 vertebrae. T-scores and bone mineral density values were calculated by DXA and QCT method, respectively. Comparative assessment of the findings was performed and statistical analysis was applied. QCT measurements found more COPD patients with impaired bone mineral density compared to DXA, namely, 13 (35.1%) versus 12 (32.4%) patients with osteopenia and 16 (43.2%) versus 9 (16.2%) patients with osteoporosis (p = 0.04). More vertebrae were found with osteoporosis by QCT compared to DXA (p = 0.03). The prevalence of osteoporosis among male patients with COPD is increased and DXA may underestimate this risk. QCT measurements have an improved discriminating ability to identify low BMD compared to DXA measurements because QCT is able to overcome diagnostic pitfalls including aortic calcifications and degenerative spinal osteophytes.

3.
Knee Surg Sports Traumatol Arthrosc ; 23(1): 232-9, 2015 Jan.
Article in English | MEDLINE | ID: mdl-23595538

ABSTRACT

PURPOSE: Anterior cruciate ligament (ACL) rupture is associated with meniscal tears and/or articular cartilage damage. The aim of this study was twofold: (a) to report and correlate the incidence of meniscal and cartilage lesions in ACL-deficient knees with time from injury and (b) to correlate lesions of menisci and cartilage with widely used knee scores. METHODS: Data were analysed from 109 consecutive patients with ACL rupture. Meniscal and articular cartilage lesions were documented during the arthroscopic reconstruction of the ACL. Patients were distributed into 3 groups according to time from injury; group A: 0-3 months (35 patients), group B: 3-12 months (39 patients) and group C: more than 12 months (35 patients). Lysholm, KOOS and IKDC rating scales were recorded preoperatively. Logistic regression analyses were applied to correlate the concomitant intra-articular pathologies with the time from injury and knee-rating scales. RESULTS: Of 109 patients, 32 (29%) had a medial meniscus tear, 20 (19%) had a lateral meniscus tear, 17 (15%) had both menisci torn and 40 (37%) had no meniscal tear. Analysis revealed that time from injury was not a significant factor for the presence of a meniscal lesion. The odds of development of a high-grade cartilage lesion in an ACL-deficient knee reconstructed more than 12 months from time from injury are 5.5 and 12.5 times higher when compared with knees that underwent ACL reconstruction less than 3 months and between 3 and 12 months after knee injury, respectively. No association was found between intra-articular pathology and the KOOS and Lysholm scores. A positive correlation between the IKDC score and patients without any intra-articular pathology was found. CONCLUSIONS: The presence of high-grade cartilage lesions is significantly increased in an ACL-deficient knee when reconstruction is performed more than 12 months after injury. However, the incidence of meniscal tears is not increased significantly. Correlation of intra-articular pathology in ACL-deficient knees with knee-rating scales is weak. LEVEL OF EVIDENCE: Diagnostic study, Level II.


Subject(s)
Anterior Cruciate Ligament Injuries , Cartilage Diseases/diagnosis , Cartilage, Articular/injuries , Knee Injuries/diagnosis , Knee Joint/surgery , Tibial Meniscus Injuries , Adolescent , Adult , Anterior Cruciate Ligament/surgery , Anterior Cruciate Ligament Reconstruction , Cartilage Diseases/surgery , Cartilage, Articular/surgery , Female , Humans , Knee Injuries/surgery , Male , Menisci, Tibial/surgery , Middle Aged , Rupture , Time Factors
4.
J Clin Densitom ; 13(2): 175-80, 2010.
Article in English | MEDLINE | ID: mdl-20347365

ABSTRACT

Hemiplegic patients are prone to bone loss and alterations in fat and lean mass, which ultimately affect their rehabilitation status and propensity in bone fractures. The present study aimed to evaluate body composition and bone mineral density (BMD) in stroke patients within 1st year post-stroke. Fifty-eight hemiplegic patients (36 men and 22 women) were enrolled in this prospective study. Dual-energy X-ray absorptiometry was used to assess total-body and lower-extremity BMDs (g/cm(2)), lean mass (g), and fat mass (g) after 3, 6 and 12 mo of stroke that led to hemiplegia. The Modified Ashworth Scale and the functional ambulation category were used to evaluate spasticity and ambulatory category of patients, respectively. Both sexes exhibited total-body and paretic lower-limb BMD loss, fat mass gain, and lean mass waste during the 1st 12 mo poststroke, and in most cases, statistically significant differences were found between 3 and 6 mo; however, the pattern of changes was different between males and females. Therefore, it is suggested that disability because of hemiplegia led to alterations in muscle function, which triggered skeletal and body composition changes and rendered these patients particularly prone to increased fracture risk.


Subject(s)
Body Composition , Bone Density , Hemiplegia/physiopathology , Stroke/physiopathology , Absorptiometry, Photon , Aged , Dependent Ambulation/physiology , Female , Follow-Up Studies , Hemiplegia/etiology , Hemiplegia/pathology , Humans , Male , Middle Aged , Muscle Spasticity/etiology , Muscle Spasticity/pathology , Muscle Spasticity/physiopathology , Risk Factors , Sex Factors , Stroke/complications , Stroke/pathology , Time Factors
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