ABSTRACT
The role of the protozoan parasite Toxoplasma gondii in the pathogenesis of liver disease has recently gained much interest. The aim of this study was to determine the prevalence and risk factors associated with T. gondii infection in patients with liver disease from three cities in Shandong and Henan provinces, China. A case-control study was conducted from December 2014 to November 2015 and included 1142 patients with liver disease and 1142 healthy controls. Serum samples were collected from all individuals and were examined with enzyme-linked immunosorbent assay for the presence of anti-T. gondii IgG and IgM antibodies. Information on the demographics, clinical, and lifestyle characteristics of the participants was collected from the medical records and by the use of a questionnaire. The prevalence of anti-T. gondii IgG was 19·7% in patients with liver disease compared with 12·17% in the controls. Only 13 patients had anti-T. gondii IgM antibodies compared with 12 control individuals (1·14% vs. 1·05%, respectively). The highest seroprevalence was detected in patients with liver cancer (22·13%), followed by hepatitis patients (20·86%), liver cirrhosis patients (20·42%), and steatosis patients (20%). Multivariate logistic regression analysis indicated that consumption of raw meat (odds ratio (OR) = 1·32; 95% confidence interval (CI) 1·01-1·71; P = 0·03) and source of drinking water from wells (OR = 1·56; 95% CI 1·08-2·27; P = 0·01) were independent risk factors for T. gondii infection in liver disease patients. These findings indicate that T. gondii infection is more likely to be present in patients with liver disease. Therefore, efforts should be directed toward health education of populations at high risk of T. gondii infection and measures should be taken to protect vulnerable patients with liver disease.
Subject(s)
Liver Diseases/epidemiology , Toxoplasma/isolation & purification , Toxoplasmosis/epidemiology , Adult , Aged , Aged, 80 and over , Case-Control Studies , China/epidemiology , Cities/epidemiology , Enzyme-Linked Immunosorbent Assay , Female , Humans , Liver Diseases/parasitology , Male , Middle Aged , Risk Factors , Seroepidemiologic Studies , Toxoplasmosis/parasitologySubject(s)
Head and Neck Neoplasms/surgery , Surgical Flaps , Adult , Female , Humans , Male , Middle Aged , Skin Neoplasms/surgeryABSTRACT
From May 1979 to August 1984, 112 infrahyoid myocutaneous flaps (IHMCFs) were used for reconstruction of the tongue after resection of lingual carcinoma (67 flaps in 63 consecutive cases) and for repair of defects after resection of carcinomas of buccal mucosa (23 cases), floor of mouth (8 cases), parotid gland (7 cases), and other malignancies (7 cases). Ten IHMCFs were extended to Ludwig's angle for repairing the open defect of the cheek or combined defect in the buccal mucosa and hard palate. The donor sites of 76 IHMCFs could be sutured primarily. The flap was successful in 90% of the cases (101 of 112 cases). Postoperatively, 94% of the cases (60 of 64 cases) of reconstructed tongue had good deglutition and 78% of the cases (50 of 64 cases) gave satisfactory enunciation. IHMCF is a new, versatile, reliable, and convenient flap suitable for repairing the defects in and around the oral cavity, particularly in the tongue, even in aged and weak patients.
