1.
Org Lett
; 26(15): 2928-2933, 2024 Apr 19.
Article
in English
| MEDLINE
| ID: mdl-38551465
ABSTRACT
The first asymmetric total synthesis of chuanxiongnolide L1 was achieved in 16 steps and 1.9% overall yield by employing a bioinspired chiral auxiliary strategy. The key steps involving asymmetric oxidative dearomatization of chiral amino ether and subsequent asymmetric Diels-Alder reaction of the resulting masked chiral ortho-benzoquinone were adopted.