ABSTRACT
Aim In order to study the mechanisms of underlying improving learning and memory in rodent, the effects of berberine (Ber) on EEG and EEG power spectrum were recorded in conscious rabbits.Methods EEG and EEG power spectrum were recorded in conscious rabbits with chronical implanted electrodes.Results Ber at doses of 1～4 mg?kg-1 iv showed to decrease dose_dependently the spectrum power of delta dominant frequency in cortical area and transfer the dominant frequency from delta to theta rhythm in hippocampus.Under the same conditions, the effects of physostigmine 0.1 mg?kg -1 iv on EEG were similar to Ber.Ber 2 mg?kg-1 iv reversed significantly these effects of Ber 0.05 mg/rabbit iv on EEG and power spectrum, but scopolamine butylbromide 0.4 mg?kg-1 iv, which can not pass the blood_brain barrier, did not.Conclusion The effects of Ber are closely related to the action on the central cholinergic system.
