[Pathogenetic mechanisms of impaired intestinal microflora in patients with destructive pulmonary tuberculosis]. / Patogeneticheskie mekhanizmy disbakterioza kishechnika u bol'nykh destruktivnym tuberkulezom legkikh.

Following 2-3 months of combined chemotherapy, most (97.5%) patients with destructive pulmonary tuberculosis were found to develop pathological changes in the intestinal microflora. Of them 92.3% had bifidobacterium deficiency, which creates conditions for opportunistic microorganisms to colonize the bowel, promoting the development of an inflammatory process in the gastroduodenal area, Bifidobacterium deficiency being a pathogenetic factor and opportunistic microbes acting as an etiological factor of the impaired intestinal microflora. Assessing of dysbiotic impairments makes it possible to specify the mechanisms of development of toxic reactions and inflammatory processes in the digestive tract.

[Bacteriologic examination for tuberculosis in subjects from a group at risk]. / Bakteriologicheskoe obsledovanie na tuberkulez lits iz grupp riska.

Laboratory methods were used to test the samples taken from 55,068 people for M. tuberculosis. Inoculation of diagnostic material for M. tuberculosis was accompanied in a number of cases by a parallel method of luminescent microscopy for the same purpose. Methods of examining the patients with non-specific lung and genitourinary diseases were developed. They consist in a preliminary step-by-step selection of diagnostic material by means of luminescent microscopy and the use of these rapid techniques, like indicator strips, making it possible to examine a great number of population within a short period of time. The expenses of step-by-step laboratory examination of risk group subjects are 4.8 times lower than those incurred with routine methods of bacteriological screening.