1.
J Med Primatol
; 52(5): 290-293, 2023 10.
Article
in English
| MEDLINE
| ID: mdl-37658590
ABSTRACT
HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.
Subject(s)
HIV-2 , Humans , Animals , Mice , HIV-2/genetics , Serial Passage , Viral Load
2.
J Med Primatol
; 52(5): 294-297, 2023 10.
Article
in English
| MEDLINE
| ID: mdl-37658595
ABSTRACT
HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4+ T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.