Subject(s)
DNA Methylation , Epigenesis, Genetic , Histones/genetics , Leukemia, Myeloid, Acute/genetics , Multigene Family , Aged , Biomarkers/metabolism , Chromatin/metabolism , Female , Gene Expression Profiling , Gene Expression Regulation , Gene Expression Regulation, Leukemic , Humans , Male , Middle Aged , Mutation , Nuclear Proteins/genetics , NucleophosminABSTRACT
OBJECTIVE: To study patient tolerability of brain imaging that employs an ultrahigh field (7 T) MR system METHODS: We examined 180 subjects that underwent brain MR examination at 7 T. A tolerability test consisting of two parts (during patient table motion and during the examination) was administered to all subjects in order to monitor their discomfort. The scores range from 0 to 5 for the first part, and from 0 to 10 for the second part, the total score of each subject therefore ranging from 0 (no side effects reported) to 15 (lowest tolerability) RESULTS: A total of 51% of subjects reported at least one side effect but all were mild in intensity and did not require examination interruption. No serious adverse event was reported. The total score (mean ± standard deviation) was 1.1 ± 1.5 out of 15 (mean score 0.4 ± 0.7 out of 5 during patient table motion and 0.7 ± 1.1 out of 10 during MR). Patient discomfort was not related to gender or health status, but it was reduced with time after system installation with increasing operator experience in performing UHF MR examinations. CONCLUSIONS: Ultrahigh field MRI is well tolerated without excessive discomfort to subjects. KEY POINTS: ⢠7-T MRI is well tolerated with low incidence of side effects ⢠The subjects' discomfort during 7-T MRI is reduced as the operators' experience increases ⢠7-T MRI is practicable in healthy subjects and patients with neurodegenerative diseases.
Subject(s)
Brain Diseases/diagnosis , Brain/pathology , Brain/radiation effects , Magnetic Resonance Imaging/methods , Radiation Tolerance , Adolescent , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Magnetic Fields , Male , Middle Aged , Prospective Studies , Reproducibility of Results , Surveys and Questionnaires , Time Factors , Young AdultABSTRACT
Pleural mesotheliomas are usually reported after a long interval has passed since first exposure to asbestos. We, however, describe a case observed after a latent period of only 7.5 years in a worker exposed in a factory manufacturing auxiliary products for wine treatment, including chrysotile asbestos filters. The exposure to asbestos lasted 3-4 months per year, during which airborne fiber concentrations ranged from 1 to 4 ff/cc in the patient's workplace. Due to the characteristics of the manufacturing process, the asbestos fibers were very thin in diameter. The patient also suffered from nasal breathing impairment. An examination of the literature showed that asbestos-related mesotheliomas have been reported, albeit rarely, after less than 10 years from onset of exposure. Therefore, it is believed that this case should be related to past exposure to asbestos.
