ABSTRACT
Polydimethylsiloxane (silicone) implants were subcutaneously placed in the back of diabetic and normal rats. After three months the rats were killed and the fibrous capsule around the implants was histologically and biochemically examined. A significant quantitative difference (p less than 0.001) was found in the thickness of the capsules, which were two to three times thicker in the diabetic animals. The biochemistry showed an increase of neutral salt-soluble collagen in the diabetic group; electrophoresis revealed only type I collagen in the diabetic and type I and III in the normal rats. From this experimental trial it seems that diabetes mellitus is another factor in formation of a thick capsule around silicone implants.
Subject(s)
Breast , Diabetes Mellitus, Experimental/pathology , Prostheses and Implants/adverse effects , Silicone Elastomers/adverse effects , Animals , Blood Glucose/analysis , Diabetes Mellitus, Experimental/metabolism , Dimethylpolysiloxanes/adverse effects , Disease Models, Animal , Glucose Tolerance Test , Prosthesis Failure , Rats , Skin/drug effects , Skin/metabolism , Skin/pathologyABSTRACT
Silicone implants were placed in the nasal, cheek, and chin areas in children with Down's syndrome to improve facial appearance. Clinical and radiologic follow-up evaluation revealed significant crater-like bone resorption in the mandibular symphysis in 75% of the cases. All of these implants were removed, and the bone showed regrowth to the presurgical state. No sign of bone damage was present in the malar or nasal areas.
Subject(s)
Bone Resorption/etiology , Chin , Dimethylpolysiloxanes , Down Syndrome/surgery , Mandibular Diseases/etiology , Mandibular Prosthesis/adverse effects , Silicones , Adolescent , Adult , Child , Child, Preschool , Chin/physiology , Chin/surgery , Female , Humans , Male , Nasal Bone/surgery , Surgery, Plastic , Wound Healing , Zygoma/surgeryABSTRACT
Twenty-two patients with congenital and acquired defects, rehabilitated with silicone ectoprostheses, were followed up for 6 mo to 4 yr. The simplicity of the procedure, its good results and the early physical and social rehabilitation attained, favor its use when adequately indicated.
