1.
Chem Commun (Camb)
; 55(13): 1939-1942, 2019 Feb 07.
Article
in English
| MEDLINE
| ID: mdl-30681091
ABSTRACT
Herein, we report a new prebiotically plausible pathway towards a pyrimidine nucleobase in continuous manner. The route involves simultaneous methylation and carbamoylation of cyanoacetylene-derived α,ß-unsaturated thioamide with N-methyl-N-nitrosourea (MNU) in aqueous media. This provides S-methylpyrimidinone in one-pot, which can be converted into a variety of 4-substituted pyrimidine nucleobases including cytosine and uracil.