ABSTRACT
The youngest patient with eosinophilic meningoencephalitis to be reported from Australia, an 11-month-old girl, is presented here. The diagnosis of angiostrongyliasis was based on the exclusion of other possibilities, the strongly-positive results of serological examination and the findings of an environmental survey. Clinical signs of serious brain damage, with persistent blindness, profound mental retardation, spasticity and epilepsy more than three years later, indicate that this infection is not always as benign as is considered generally.
Subject(s)
Eosinophilia/diagnosis , Meningoencephalitis/diagnosis , Angiostrongylus/immunology , Angiostrongylus/isolation & purification , Animals , Antibodies/analysis , Enzyme-Linked Immunosorbent Assay , Eosinophilia/complications , Eosinophilia/etiology , Female , Humans , Infant , Meningoencephalitis/complications , Meningoencephalitis/etiology , Nematode Infections/complications , Nematode Infections/diagnosis , Nematode Infections/transmissionSubject(s)
Antineoplastic Agents/administration & dosage , BCG Vaccine/administration & dosage , Leukemia, Lymphoid/therapy , Child , Child, Preschool , Clinical Trials as Topic , Drug Therapy, Combination , Female , Humans , Immunotherapy , Infant , Leukemia, Lymphoid/drug therapy , Leukemia, Lymphoid/pathology , Leukocyte Count , Male , Probability , Prognosis , Random Allocation , RecurrenceSubject(s)
Breast Feeding , Diet, Vegetarian , Vitamin B 12 Deficiency/etiology , Adult , Female , Humans , InfantABSTRACT
Aggressive chemotherapy and prophylactic central nervous system irradiation have increased the survival time of children with acute lymphatic leukaemia. As a result of treatment complex neurological problems are appearing. Computerized axial tomography allows more definite elucidation of these problems. 7 of 11 treated patients studied by this technique showed the presence of intracranial calcification and patchy cerebral atrophy, raising the questions of the quality of survival and the relationship of the findings to the cytotoxic drugs used.
Subject(s)
Brain Diseases/etiology , Calcinosis/etiology , Leukemia, Lymphoid/complications , Atrophy , Brain Diseases/diagnostic imaging , Calcinosis/diagnostic imaging , Child , Child, Preschool , Humans , Tomography, X-Ray ComputedSubject(s)
Acetohexamide/adverse effects , Chlorpropamide/adverse effects , Hypoglycemia/chemically induced , Infant, Newborn, Diseases/chemically induced , Pregnancy in Diabetics/drug therapy , Acetohexamide/blood , Chlorpropamide/blood , Exchange Transfusion, Whole Blood , Female , Fetus , Humans , Hypoglycemia/therapy , Infant, Newborn , Insulin/blood , Male , Maternal-Fetal Exchange , PregnancyABSTRACT
Three infants whose diabetic mothers were given chlorpropamide and one infant whose diabetic mother was given acetohexamide up to the time of delivery were studied in the neonatal period because each became severely hypoglycaemic. The sulphonylurea drugs given to the mother crossed the placenta, and fetal plasma concentrations were in the therapeutic range for adults with diabetes mellitus. Each baby had severe hyperinsulinaemia resulting in profound hypoglycaemia. These acutely ill infants needed vigorous and prolonged treatment to correct the hypoglycaemia. In two infants exchange transfusion was performed to remove the drug. These sulphonylurea drugs should not be used to control diabetes mellitus in pregnancy. (AU)
