ABSTRACT
Amyloid-ß peptide Aß(25-35) was shown to cause lysis of rat erythrocytes of different ages. The toxicity of Aß(25-35) positively correlated with both the erythrocyte age andthe peptide concentration. The activity of glycolytic, antioxidant, and Na+/K(+)-ATPase enzymes decreased with erythrocyte aging in vivo. In vitro Aß(25-35) reduced the activity of hexokinase, phosphofructokinase, pyruvate kinase, glutathione peroxidase, and glutathione transferase and increased Na+/K(+)-ATPase activity in aged erythrocytes to a greater degree than in young cells.
Subject(s)
Alzheimer Disease/metabolism , Amyloid beta-Peptides/administration & dosage , Erythrocytes/drug effects , Sodium-Potassium-Exchanging ATPase/biosynthesis , Aging/metabolism , Alzheimer Disease/pathology , Animals , Erythrocytes/enzymology , Humans , RatsABSTRACT
We studied 1387 patients with different forms of syphilis for neurological deficiency. Thirty patients had vascular neurosyphilis. Two cases are described in detail. A 40-year-old man had recurring episodes of acute disturbance of the cerebral blood flow and progressive cognitive disorders. A 32-year-old patient presented with progressive dementia, hallucinatory symptoms and minor multifocal neurological changes. The diagnosis of neurosyphilis was verified by CSF-test results. The diagnosis of cerebral vasculitis was proved by the data of magnetic resonance imaging (MRI), magnetic resonance (MR) angiography, ophthalmological methods, and duplex scanning of brachiocephalic arteries, transcranial duplex scanning. Diagnostic criteria of syphilitic cerebral vasculitis were defined and presented.
Subject(s)
Neurosyphilis/diagnosis , Vasculitis, Central Nervous System/diagnosis , Adult , Diagnostic Techniques, Ophthalmological , Humans , Magnetic Resonance Angiography , Male , Neurosyphilis/cerebrospinal fluid , Neurosyphilis/physiopathology , Vasculitis, Central Nervous System/cerebrospinal fluid , Vasculitis, Central Nervous System/physiopathologyABSTRACT
The present study included 86 children aged between 7 and 17 years with type 1 diabetes mellitus from 1 to 15 years in duration. In all the patients, renal blood flow was investigated with the use of ultrasonic dopplerography. The results of the study suggest disturbances of intrarenal hemodynamics that manifested themselves as enhanced resistance of renal arteries from periphery to the centre in the patients at the hyperfiltration stage of diabetic nephropathy (DN) in conjunction with the reduced velocity of blood flow in inter-lobular and segmental arteries. In contrast, the patients at the microalbuminuric stage of diabetic nephropathy exhibited increased resistance and reduced velocity of blood flow in the main renal veins. In 35 patients presenting with diabetic nephropathy, hemodynamic correction was achieved by the application of the traveling pulsed magnetic field (TP-MF) to the renal region using an AMO-ATOS-E apparatus (Russia). This treatment resulted in normalization of the characteristics of renal blood flow. It is concluded that TPMF has good prospects for the use as a component of the combined treatment of diabetic nephropathy.
Subject(s)
Diabetic Nephropathies , Magnetic Field Therapy , Renal Artery/diagnostic imaging , Renal Artery/physiopathology , Renal Circulation , Vascular Resistance , Adolescent , Blood Flow Velocity , Child , Child, Preschool , Diabetic Nephropathies/diagnosis , Diabetic Nephropathies/diagnostic imaging , Diabetic Nephropathies/physiopathology , Diabetic Nephropathies/therapy , Echocardiography, Doppler, Color/methods , Female , Humans , Infant , MaleABSTRACT
Arginase activity in erythrocytes is higher in patients with arterial hypertension and atherosclerosis as compared with healthy people. Therapy with either lisinopril alone or in combination with simvastatin for 3-6 months causes a decrease in the arginase activity to the control level. Both the monotherapy and the combination therapy increased the concentrations of NO2(-), NO3(-), and total NOO2(-) + NO3(-)in the plasma of hypertensive patients. The NO2(-) + NO3(-) concentration in erythrocytes decreases in hypertensive patients but is completely restored after therapy with lisinopril alone or in combination with simvastatin. Thus, lisinopril and lisinopril plus simvastatin display a pronounced and equal normalizing effect on arginase activity in human erythrocytes, which is elevated in hypertension, as well as on the endothelial nitric oxide synthase activity, which is decreased in hypertension.
Subject(s)
Arginase/drug effects , Lisinopril/pharmacology , Nitrates/blood , Nitrites/blood , Simvastatin/pharmacology , Adult , Aged , Arteriosclerosis/drug therapy , Drug Combinations , Erythrocytes/drug effects , Erythrocytes/enzymology , Female , Humans , Hypertension/drug therapy , Male , Middle Aged , Nitric Oxide Synthase Type III/drug effectsABSTRACT
We report results on event-by-event fluctuations of transverse momentum, Phi(p(t)), in pi(+)p and K(+)p collisions at 250 GeV/c. For the first time, their dependence on rapidity region, transverse momentum acceptance, multiplicity, mean transverse momentum per event, and on the correlation between transverse momentum and multiplicity are systematically presented. The results are compared with those from the PYTHIA Monte Carlo generator. The fluctuations under the same acceptance cuts as used in current heavy-ion experiments are also presented.
