[Use of quantitative histochemistry in the prognosis of renal cell cancer]. / Primenenie kolichestvennoi gistokhimii v prognoze pri pochechno-kletochnom rake.

The study was concerned with evaluating the quantitative histochemical and histoenzymatic peculiarities of renal cell carcinoma of various grade of malignancy. It involved measuring levels of lipids, glycogen, protein, nucleic acids and sugar as well as the activities of dehydrogenases, phosphatases, non-specific esterase and lipase in tumor cells. Grade I neoplasms were found to be associated with low proliferative activity matched by relatively high energy production thus causing excessive synthesis of lipids and glycogen to occur. Higher cell proliferative activity in grade II and III tumors accounts for a significantly lower level of lipids and glycogen. Those metabolic peculiarities appeared to correlate with prognosis.

[The degree of malignancy and histologic variants of kidney cancer: their importance in diagnosis and prognosis]. / Stepen' zlokachestvennosti i gistologicheskis varianty raka pochek: znachenie dlia diagnoza i prognoza.

Basing on quantitative morphological and histochemical findings, 170 cases of renal carcinoma were divided into 3 (I, II, III) grades of malignancy. This grading system is of a high prognostic significance. Histological variant, i.e. the predominance of clear or granular cells in the tumor specimens, is not prognostically significant. The clear cells differ from the granular ones by high lipid and glycogen content and by low proliferation rate. In tumors of a high malignancy grade the lipid and glycogen levels are low. The authors offer to divide all cases of renal carcinoma not into clear- and granular-cell tumors, but on lipid-rich and lipid-poor ones because the lipid content is in good correlation with the grade of malignancy and therefore prognostically valuable.