ABSTRACT
This paper focuses on the risk factors of primay and secondary proliferative vitreoretinopathy, modern views of pathophysiology of this disease, and the role of inflammation in its development. Special attention is given to the involvement of pigment epithelial cells, macrophages, hyalocytes, gliocytes, supporting fibers (Muller's cells), mediators of inflammation, such as cytokines, chemokines, and growth factors, with reference to their interaction in the processes of proliferation and development of retinal membranes.
Subject(s)
Inflammation/metabolism , Vitreoretinopathy, Proliferative , Cytokines/blood , Ependymoglial Cells/pathology , Humans , Intercellular Signaling Peptides and Proteins/blood , Retinal Pigment Epithelium/pathology , Vitreoretinopathy, Proliferative/metabolism , Vitreoretinopathy, Proliferative/pathology , Vitreoretinopathy, Proliferative/physiopathologyABSTRACT
In this article we review and discuss the advantages of two proliferative vitreoretinopathy models in rats: intravitreal injection of proteolytic enzyme dispase and proinflammatory lectin concanavalin A. For the first time we selected clear morphological criteria for the retina evaluation during the inflammatory response. We also compared the effects of the injection of dispase and concanavalin on the 7th day after the drugs administration. We conclude that different doses of dispase can be used to get a stable model of PVR on different periods after the injection procedure.
