ABSTRACT
Using the methods of light and electron microscopy, morpho-functional changes of the ovaries of albino rats after their monopolar coagulation were studied. Electrocoagulation was shown to cause hemodynamic changes in a perifocal area and short-term stimulation of follicular growth, but starting already at postoperational day 3, their atresia was increased, while by day 30 a significant reduction in number of both primordial and growing follicles, as well as of corpora lutea, was found. Ultrastructural changes of oocytes in primary and secondary follicles outside the coagulation zone were demonstrated at early stages and included the reduction of porous plate, cortical and yolk granule numbers, and the increase in numbers of lysosomes and multivesicular bodies. Ascovertin, due to its antioxidant properties and by improving hemorheological parameters, exerts a protective action on ovarian generative apparatus and the state of microcirculation in the organ.
Subject(s)
Antioxidants/pharmacology , Ascorbic Acid/pharmacology , Ovary/drug effects , Ovary/ultrastructure , Quercetin/analogs & derivatives , Regeneration/drug effects , Animals , Drug Combinations , Electrocoagulation , Female , Flavonols/pharmacology , Ovary/physiology , Quercetin/pharmacology , RatsABSTRACT
On the original experimental model of chronic inflammation of the ovaries and oviducts in white rats it was established that electrophoresis of 1% esobel solution prevents an increase in the specific volume of interstitial connective tissue, development of fibrosclerotic alterations and adhesive process. Peloidophysiotherapy normalizes growth and atresia of the ovarian follicular system. Thus, electrophoresis of 1% esobel solution is highly effective in combined treatment of chronic inflammatory diseases of the uterine appendages.
Subject(s)
Mud Therapy/methods , Oophoritis/therapy , Salpingitis/therapy , Sulfides/administration & dosage , Adult , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Disease Models, Animal , Female , Humans , Iontophoresis , Rats , Treatment OutcomeABSTRACT
A course of ultraphonophoresis of the extract of high-polar lipids of sulfide mud attenuated inflammation of uterine appendages in rats caused by catgut suturing of the ovaries and oviducts. On postoperative day 75-120 peloid therapy resulted in degradation of the suture material and its replacement with connective tissue. The peloid limited postoperative intensification of follicular atresia, raised content of growing follicles and yellow bodies in the ovaries.
Subject(s)
Fallopian Tubes/surgery , Mud Therapy/methods , Ovary/surgery , Phonophoresis/methods , Sutures/adverse effects , Animals , Fallopian Tubes/pathology , Female , Ovary/pathology , Postoperative Complications/pathology , Postoperative Complications/therapy , Rats , Treatment OutcomeABSTRACT
Experimental and clinical investigations have demonstrated that the addition of abdominal-sacral electrophoresis of esobel 1% solution to combined therapy of acute inflammation of the uterine appendages improves treatment results. Bioantioxidants bring about the antiinflammatory action of the mud preparation esobel while its high-polar lipids prevent structural-metabolic impairment of the appendages' tissue elements as shown by a pronounced antiexudative effects and weak secondary alteration.
Subject(s)
Iontophoresis/methods , Mud Therapy/methods , Pelvic Inflammatory Disease/rehabilitation , Acute Disease , Adnexa Uteri/ultrastructure , Adolescent , Adult , Animals , Combined Modality Therapy , Female , Humans , Microscopy, Electron , Pelvic Inflammatory Disease/immunology , Pelvic Inflammatory Disease/pathology , Rats , Statistics, Nonparametric , Time FactorsABSTRACT
Ultrastructural changes of blood vessels of ovaries and oviducts, destruction of the part of follicular epitheliocytes and disruption of other structures of blood-follicular barrier occur at the early period of experimental inflammations of appendage uterus on the background of traditional antibiotic therapy. All changes lead to atresia of growing follicules. Fibrotic-sclerotic changes develop on the 30th day and during later period. Course of eplir phonophoresis decreases ultrastructural disruptions of vessels, follicular apparatus of ovaries and oviducts epithelium. Effect of physiotherapy is manifested though activity of fibroclasts and macrophages, that regulate collagen production/resorption ratio thus preventing the development of fibrotic changes of ovary stroma and oviduct wall.
Subject(s)
Carotenoids/administration & dosage , Fallopian Tubes/ultrastructure , Mud Therapy/methods , Oophoritis/pathology , Ovary/ultrastructure , Phonophoresis/methods , Phospholipids/administration & dosage , Salpingitis/pathology , Staphylococcal Infections/pathology , Acute Disease , Animals , Disease Models, Animal , Drug Combinations , Female , Microscopy, Electron , Oophoritis/rehabilitation , Rats , Salpingitis/rehabilitation , Staphylococcal Infections/rehabilitation , Time FactorsABSTRACT
Ultraphonophoresis of 1% oil solution of eplir in patients with acute inflammation of the uterine appendages as an adjuvant to drug therapy enhances the latter by immediate (anesthetic, antiexudative action), short-term (immunocorrection) and long-term (preservation and restoration of reproductive function, prevention of chronicity) treatment results.
Subject(s)
Inflammation/therapy , Mud Therapy , Uterine Diseases/therapy , Female , Humans , Inflammation/metabolism , Inflammation/physiopathology , Phonophoresis/methods , Uterine Diseases/metabolism , Uterine Diseases/physiopathologyABSTRACT
Eplir ultraphonophoresis started on day 5 of experimental inflammation of the uterine appendages in the presence of antibacterial therapy reduces the severity of exudative processes, hemodynamic disorders, leukocytic infiltration, follicular atresia, prevents growth of connective tissue stroma.
Subject(s)
Carotenoids/administration & dosage , Mud Therapy/methods , Pelvic Inflammatory Disease/rehabilitation , Phonophoresis/methods , Phospholipids/administration & dosage , Animals , Anti-Infective Agents/therapeutic use , Combined Modality Therapy , Drug Combinations , Evaluation Studies as Topic , Female , Pelvic Inflammatory Disease/drug therapy , Pelvic Inflammatory Disease/pathology , Rats , Time Factors , Uterus/ultrastructureABSTRACT
Two-stage electrophoresis of preparations made of natural brine and extract of mud taken from the Lake Karachi tried in combined treatment of experimental inflammation of the uterine appendages prevents proliferative and sclerotic alterations in ovarian stroma, stimulates repair of the intramural nerves, corrects follicular atresia.
