[Assessment of Vascular Stiffness in Normotensive Patients With Familial Hypercholesterolemia].

AIM: to analyze parameters of vascular stiffness and augmentation index in patients with familial hypercholesterolemia (FH). MATERIALS AND METHODS: We compared parameters of vascular stiffness of 88 normotensive FH patients (mean age 41.95±1.43 years, 43 men [48.9 %]) and 68 subjects with normal blood lipid spectrum (mean age 37.58±1.02 years, 21 men [30.9 %]). FH was diagnosed according to the criteria of the Dutch Lipid Clinic Network. Examination included lipid profile, 24­hour blood pressure (BP) monitoring with assessment of arterial stiffness. RESULTS: Normotensive FH patients had higher pulse wave velocity (PWV) (7.99±0.17 m/s) in comparison with patients with normal lipid spectrum (6.87±0.10 m/s), p.

[Effect of preoperative infusion volume on frequency of intraoperative nausea and vomiting as complications of spinal anaesthesia in pregnant women during caesarian operation (pilot study)].

Purpose of the study was to define a prophylactic effect of different preload volumes on the rate of intraoperative nausea and vomiting (IONV) as a complication due to spinal anaesthesia (SA) during caesarian operation (SO) in parturient. Data for analysis was collected during clinical observational multi-center research included several medical centers. Statistics involved originally developed method allowed to analyze relative risk changing along the entire interval of all applied preload volumes. The results suppose that preload is effective method of IONV prophylactics in parturient during SO under SA if only infused preload volumes do not break specially determined limits of effective interval. If preload volume value is out of this range then preinfusion may lead to increasing risk of IONV occurrence.

[Heart function changes during pregnancy].

The aim of the study was to assess the left ventricle (LV) systolic and diastolic functions during normal pregnancy. Patients were divided in 2 groups: women with normal pregnancy (30-40 weeks) and a control group--healthy non-pregnant women. Echocardiography and tissue Doppler imaging (TDI) were registered in both groups. Women age, height and weight were additionally registered. Static handling included correlation analysis with calculation of Pearson and Spirmen pair factors correlation. Obtained data showed that stroke volume during pregnancy plays a key role not only in minute volume increase, but also in its regulation in general. Preload and stroke volume increase during constant heart rate is in need of systolic and diastolic LV walls movement speed and myocardium contractility function increase. Results of our research explain imperfection of pregnant women adaptable mechanisms to hypertransfusions and heavy hypovolemia.

[Gas exchange and respiration mechanics during high-frequency jet ventilation of the lungs]. / Gazoobmen i mekhanika dykhaniia pri struinoi vysokochastotnoi iskusstvennoi ventiliatsii legkikh.

Gas exchange and pulmonary mechanics in high frequency-jet ventilation (HFJV) were studied during intubation anesthesia in patients with normal respiratory organs. The HFJV frequency ranged from 100 to 400 per minute. The tidal volumes (VT) varied from 50 to 140 ml. Gas exchange was studied in 11 patients, the total number of regimens amounting to 69. The physiological dead space volume (VD) was determined by the Bohr method for different combinations of VT and frequency after 15-minute ventilation with each regimen. The values of VD and VA were found to have linear relationships with VT and no relation to the ventilation frequency. Linear regression equations were derived for these relationships. The dynamic pulmonary distension in HFJV was assessed in 9 patients using the interrupted HFJV techniques, up to 28 regimen being tested for each patient. An exponential relationship between the accumulated gas volume and VT was found at fixed frequency values and duration of the expiratory phase. The regimen capacity for inducing gas accumulation in the lungs is determined by the ratio of ventilation frequency to the expiration time (accumulation coefficient). The dynamic pulmonary distention in HFJV is attended with a rise in mean respiratory pressure which, however, remains lower than the mean alveolar pressure. The obtained evidence should be taken into account when choosing an optimal regimen for individual HFJV.