1.
J Antibiot (Tokyo)
; 44(12): 1312-7, 1991 Dec.
Article
in English
| MEDLINE
| ID: mdl-1778784
ABSTRACT
The dunaimycins are a new complex of spiroketal 24-membered macrolides discovered in the fermentation broth of two actinomycetes. Based on taxonomic studies these two cultures, which were isolated from soil, were identified as Streptomyces diastatochromogenes strains AB 1691Q-321 and AB 1711J-452. The dunaimycins possess both immunosuppressive and antimicrobial activity.
Subject(s)
Anti-Bacterial Agents/isolation & purification , Antifungal Agents/isolation & purification , Fermentation , Immunosuppressive Agents/isolation & purification , Streptomyces/classification , Anti-Bacterial Agents/metabolism , Anti-Bacterial Agents/pharmacology , Antifungal Agents/biosynthesis , Antifungal Agents/pharmacology , Immunosuppressive Agents/metabolism , Immunosuppressive Agents/pharmacology , Macrolides , Microbial Sensitivity Tests , Streptomyces/metabolism
2.
J Antibiot (Tokyo)
; 43(3): 223-8, 1990 Mar.
Article
in English
| MEDLINE
| ID: mdl-2324007
ABSTRACT
The altromycins are novel anthraquinone-derived antibiotics related to the pluramycins. They are produced by an actinomycete, AB 1246E-26, which was isolated from a South African bushveld soil. The altromycins have Gram-positive antibacterial activity with MICs of 0.2 to 3.12 micrograms/ml against Streptococci and Staphylococci.
