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Immunity ; 16(6): 779-90, 2002 Jun.
Article in English | MEDLINE | ID: mdl-12121660

ABSTRACT

An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.


Subject(s)
CD4-Positive T-Lymphocytes/physiology , Carrier Proteins/analysis , Glutathione Transferase , Glycoproteins/analysis , Interleukins/physiology , Th1 Cells/immunology , Amino Acid Sequence , Antigen-Presenting Cells/metabolism , Cell Division , Dimerization , Interferon-gamma/biosynthesis , Interleukin-12/physiology , Interleukins/chemistry , Minor Histocompatibility Antigens , Molecular Sequence Data , Protein Conformation , Receptors, Cytokine/metabolism , Receptors, Interleukin , Sequence Alignment
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