ABSTRACT
Ectopic pregnancy is the leading cause of maternal morbidity and mortality during the first trimester of pregnancy. There has been a dramatic increase in its incidence since the advent of IVF followed by in vitro Embryo Transfer (IVF-ET). Many risk factors related to IVF techniques and the cause of infertility have been documented. The combination of Endo Vaginal Ultrasonography and Human B Chorionic Gonadotropin (HCG) assays is the most reliable diagnostic tool, sometimes allowing the trunk to be preserved.
Grossesse extra-utérine est la principale cause de morbidité et mortalité maternelles durant le premier trimestre de la grossesse. On note une augmentation spectaculaire de son l'incidence depuis l'avènement de la FIV suivi du Transfert de l'Embryon in vitro (FIV-ET). De nombreux facteurs de risque liés aux techniques de la FIV et la cause de l'infertilité ont été documentés. La combinaison de l'échographie Endo vaginale au dosage des B gonadotrophines chorioniques humaines (HCG) est l'outil de diagnostic le plus fiable, permettant parfois de conserver la trompe.
ABSTRACT
Bilharzia is the world's second parasitic endemic and its genito-urinary lesions are well described. Ectopic pregnancies on tubal obstruction by bilharzia eggs are reported in African populations. Through a case of clinical observation we report an exceptional case of tubal erythema tubal bilharziasis in a French woman of origin but particularly affectionate by the African woman Africa south of the sahara. where she carries out humanitarian activities in countries in conflits (Democratic Republic Of Congo, Ivory Coast, and Mali).
La bilharziose est la seconde endémie parasitaire mondiale et ses atteintes génito-urinaires sont bien décrites. Les grossesses ectopiques sur salpingite bilharziennes ont rapportées dans les populations Africaines. Nous vous rapportons un cas exceptionnel. de grossesse extra-utérine sur bilharziose tubaire chez une française d'origine mais particulièrement affectionnée par l'Afrique au sud du saharienne où elle mène des activités humanitaires dans les pays Africains en conflits armées (République Démocratique Congo, Côte d'Ivoire, et Mali).
ABSTRACT
INTRODUCTION: Human placental stem villi (PSV) present contractile properties. We studied the role of actin-myosin cross bridges (CBs) and the effects of NO-cGMP pathway modulators in the PSV contraction and relaxation. METHODS: In vitro contractile properties were investigated in 71 PSV from term human placentas studied according to their long axis. Contraction was induced by both KCl and electrical tetanic stimulation. Relaxation was induced by inhibiting the CB cycle with either 2,3-butanedione monoxime (BDM) or blebbistatin (BLE) and by activating the NO-cGMP pathway with isosorbide dinitrate (ISDN), sildenafil (SIL) or ISDN + SIL. RESULTS: PSV tension slowly increased by 140% of the basal tone after KCl exposure and by 85% after tetanus. The addition of BDM, BLE, ISDN, SIL and ISDN + SIL induced a relaxation of PSV, the overall time course of relaxation (in s) was respectively (means ± SD) 3412 ± 1904, 14,250 ± 3095*, 3813 ± 1383, 2883 ± 1188 and 2440 ± 477; significantly longer in BLE compared with BDM, ISDN, SIL and ISDN + SIL:*p < 0.001). the overall time course of relaxation (in s) was respectively (means ± SD) 3412 ± 1904, 14,250 ± 3095*, 3813 ± 1383, 2883 ± 1188 and 2440 ± 477; significantly longer in BLE compared with BDM, ISDN, SIL and ISDN + SIL:*p < 0.001). These relaxation kinetics were particularly slow. Other relaxation parametres, i.e., maximum lengthening, -peak dT/dt, and resting tension, did not differ between these 5 subgroups. DISCUSSION AND CONCLUSION: Isolated human PSV were able to contract after both KCl exposure and tetanus. This increase in contractility was reversed by inhibiting the CB cycle with BDM or BLE and by stimulating the NO-cGMP pathway with ISDN or SIL. The association ISDN + SIL did not potentiate the relaxing processes.
Subject(s)
Actins/physiology , Chorionic Villi/physiology , Cyclic GMP/physiology , Myosins/physiology , Nitric Oxide/physiology , Second Messenger Systems , Actins/antagonists & inhibitors , Actins/chemistry , Chorionic Villi/chemistry , Chorionic Villi/drug effects , Cyclic GMP/agonists , Cyclic GMP/antagonists & inhibitors , Diacetyl/analogs & derivatives , Diacetyl/pharmacology , Electric Stimulation , Enzyme Inhibitors/pharmacology , Female , Heterocyclic Compounds, 4 or More Rings/pharmacology , Humans , In Vitro Techniques , Isosorbide Dinitrate/pharmacology , Kinetics , Myosins/antagonists & inhibitors , Myosins/chemistry , Nitric Oxide/agonists , Nitric Oxide/antagonists & inhibitors , Nitric Oxide Donors/pharmacology , Piperazines/pharmacology , Pliability/drug effects , Potassium Chloride/metabolism , Pregnancy , Protein Structure, Quaternary , Purines/pharmacology , Second Messenger Systems/drug effects , Sildenafil Citrate , Sulfones/pharmacology , Term BirthABSTRACT
We reported here a case of persistent polyclonal B-cell lymphocytosis (PPBL) in a 31-year-old female patient. Peripheral blood smears showed atypical binucleated lymphocytes which were polyclonal B-cells with kappa and lambda expression, and without clonal rearrangement of immunoglobulin heavy chain. Cytogenetic analysis found a trisomy 8, with premature chromosome condensation. Clinically, PPBL is associated with moderated splenomegaly, adenopathy, and smoking. It remains to be established whether PPBL is a real pathology or a simple cytological abnormality.
