[Dynamics of rheological properties of the blood in patients with breast cancer during combined treatment]. / Dinamika reologicheskikh svoistv krovi bol'nykh rakom molochnoi zhelezy v protsesse kombinirovannogo lecheniia.

The paper is devoted to the results of investigation of blood rheological features (dynamic blood and plasma viscosity) in 70 breast cancer patients during combined therapy. The basal levels of dynamic blood viscosity indices in these patients were lower by 11.6% than in the control group of healthy women (p less than 0.05). During combined therapy after a course of gamma-beam therapy (in the small fractionation regimen for the 1st group and large fractionation regimen for the 2nd group) a further decrease of blood and plasma viscosity indices was observed, reaching their minimum values on the 14th day after radical mastectomy. In a long-term period of combined therapy (5 years--the 3rd group) dynamic blood and plasma viscosity indices remained below the control values and had no significant differences from the basal values in the 1st and 2nd groups. These shifts in rheological blood features during combined therapy of breast cancer were probably of favourable nature as complications (hypostatic pneumonia, thromboses, necroses of displaces of skin grafts) in the postoperative period were absent.

[Myelodepression during antitumor therapy in hepatorenal insufficiency]. / Mielodepressiia v protsesse protivoopukholevoi terapii pri gepatorenal'noi nedostatochnosti.

The hematotoxicity of cytostatics was found enhanced if these agents were used in therapy of oncologic patients with disordered functional activity of the hepatorenal system. Decreased absorption and excretory functions of the hepatocytes or renal abnormalities associated with impaired glomerular filtration and secretory-excretory function are the factors that contribute to the development of leukopenia by the middle or end of the treatment course. This permits a conclusion on the prognostic value of examinations of liver and kidney function in cases with the development of secondary hemodepression in chemotherapy of oncologic patients.

[Scintigraphy in the evaluation of postoperative disorders of pulmonary circulation in cancer of the breast and genitalia]. / Stsintigrafiia v otsenke posleoperatsionnykh narushenii legochnogo krovotoka pri rake molochnoi zhelezy i genitalii.

Altogether 60 patients with genital tumors and breast cancer were examined on the 3rd-7th day after operation using ON-110 gamma-camera (USA). Perfusion pulmonary scintigraphy with labeled MMA was performed in all the patients. In 66% of the examinees pulmonary blood flow disorders localized mainly in the lower part of the lungs, were noted, and in breast cancer patients--on the tumor lesion side, too. Perfusion pulmonary scintigraphy was shown to be an informative method of diagnosis of postoperative changes of the capillary pulmonary circulation which were clinically undetectable.