ABSTRACT
AIM: To study airways reactivity in patients with diabetes mellitus (DM). MATERIAL AND METHODS: Berotek and histamine tests were performed in 29 DM patients (type 1 DM - 20, type 2 DM - 9 patients) and 39 DM patients (12 and 27 patients, respectively). The age of the patients varied from 16 to 66 years. RESULTS: Positive berotek test was in 6 (20.7%) patients (delta FEV1 > 200). Of them 5 had type 1 DM. Positive histamine test was registered in 9 patients with type 2 DM (23.1%). This indicates bronchial hyperreactivity (BH). A qualitative analysis with Fisher's criterion detected correlation between BH and type of DM, BH and intake of sugar reducing tablets. Correlations between BH, body mass index, diabetes duration and late complications were not found. CONCLUSION: DM patients have predisposition to bronchial spasm. Positive bronchodilation test was mainly in type 1 DM, BH in response to histamine was obtained in type 2 DM. Different mechanisms of a bronchospasm in type 1 and 2 DM are demonstrated. Predisposition to bronchospasm may play an unfavourable role in the course of nonspecific pulmonary diseases in DM patients.
Subject(s)
Bronchial Hyperreactivity/physiopathology , Diabetes Mellitus, Type 1/physiopathology , Diabetes Mellitus, Type 2/physiopathology , Fenoterol , Forced Expiratory Volume/physiology , Histamine , Adolescent , Adult , Aged , Bronchial Hyperreactivity/diagnosis , Bronchial Hyperreactivity/etiology , Bronchoconstriction/drug effects , Bronchodilator Agents , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Disease Progression , Female , Follow-Up Studies , Forced Expiratory Volume/drug effects , Histamine Agonists , Humans , Male , Middle Aged , Respiratory Function Tests/methods , Risk FactorsSubject(s)
Military Medicine , Naval Medicine , Warfare , History, 20th Century , Hospitals, Military , USSRSubject(s)
Anesthesia, General , Ether , Ethyl Ethers , Hemodynamics , Neuroleptanalgesia , Nitrous Oxide , Wounds and Injuries/surgery , HumansSubject(s)
Ovary/blood supply , Thrombophlebitis/pathology , Adult , Female , Humans , Veins/pathologyABSTRACT
The work deals with the results of the comparative evaluation of the effectiveness of vaccines developed at the Sanitary Research Institute (Zagorsk) and the Mechnikov Research Institute for Vaccines and Sera (Moscow), as well as two methods of immunization against plague, by inhalation and subcutaneous injection, under the conditions of aerosol infection. The immunogenic effectiveness of both vaccines, when evaluated in terms of LD50, was shown to be approximately the same, but the animals immunized by the inhalation method with the vaccine developed at the Sanitary Research Institute proved to be less susceptible to infection than those immunized with the vaccine developed at the Mechnikov Research Institute for Vaccines and Sera in Moscow. After immunization by the inhalation method the vaccine developed at the Sanitary Research Institute rendered more effective protection (3- to 4-fold) against aerosol infection than after immunization by subcutaneous injection. The animals immunized by the inhalation method proved to be capable of surviving plague in the primary pneumonic form.
