ABSTRACT
Three cases of cherubism belonging to the same genealogical tree which had been followed up since the age of 7 years to adulthood are presented. These cases prove that, without treatment, the regression of the lesions and bone regeneration are real and not anecdotal. Nevertheless, following spontaneous bone regeneration, radiographically some radiolucent areas of low intensity and devoid of trabeculations, and/or areas of sclerotic bone do persist. In one case, cherubism was associated with peripheral giant cell granulomas localized in areas not affected by cherubism.
Subject(s)
Bone Regeneration , Cherubism/genetics , Adult , Cherubism/pathology , Cherubism/physiopathology , Child , Female , Follow-Up Studies , Granuloma, Giant Cell/genetics , Granuloma, Giant Cell/pathology , Humans , Male , Mandibular Diseases/genetics , Mandibular Diseases/pathology , Mandibular Diseases/physiopathology , Osteosclerosis/genetics , Osteosclerosis/pathology , Remission, SpontaneousABSTRACT
Five out of 4,172 operated maxillary cysts (3 developed within the maxillary and 2 in the mandible) presented a malignant change of epithelium. In all these 5 cases histology demonstrated a transition from normal to cancerous epithelium. The overall percentage of malignant change was of 0.12%, with 0.077% for non-keratinized epithelium lining odontogenic cysts (3 cases) and 0.65%, that is 8 times higher, for keratinized ones (2 cases). Keratinization of cystic epithelium and chronic inflammatory lesions were the main risk factors.
