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7.
Ter Arkh ; 57(2): 91-5, 1985.
Article in Russian | MEDLINE | ID: mdl-2408352

ABSTRACT

Examination of the exocrine function of the pancreas in 52 workers exposed to lead, including 36 with the symptoms of intoxication (mild in 33 and marked in 3) revealed the primarily hyposecretory response of acinar cells stimulated with pancreozymin and secretin, while the hyposecretory and dyspancreatic responses were recorded less frequently. The endocrine function of the pancreas was revealed to be also lowered, which was confirmed by the decreased blood fasting insulin content and low blood insulin content after glucose intake as well. The changes in pancreatic function are among the pathogenetic mechanisms of the abdominal syndrome observable during lead intoxication.


Subject(s)
Lead Poisoning/physiopathology , Occupational Diseases/physiopathology , Pancreas/physiopathology , Amylases/antagonists & inhibitors , Amylases/deficiency , Chronic Disease , Humans , Insulin/deficiency , Insulin Antagonists , Islets of Langerhans/physiopathology , Lipase/antagonists & inhibitors , Lipase/deficiency
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